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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell
Publication : Open biology

Tissue tropism in parasitic diseases.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Open biology - 31 May 2019

Silva Pereira S, Trindade S, De Niz M, Figueiredo LM,

Link to Pubmed [PMID] – 31088251

Link to DOI – 10.1098/rsob.190036

Open Biol 2019 05; 9(5): 190036

Parasitic diseases, such as sleeping sickness, Chagas disease and malaria, remain a major cause of morbidity and mortality worldwide, but particularly in tropical, developing countries. Controlling these diseases requires a better understanding of host-parasite interactions, including a deep appreciation of parasite distribution in the host. The preferred accumulation of parasites in some tissues of the host has been known for many years, but recent technical advances have allowed a more systematic analysis and quantifications of such tissue tropisms. The functional consequences of tissue tropism remain poorly studied, although it has been associated with important aspects of disease, including transmission enhancement, treatment failure, relapse and clinical outcome. Here, we discuss current knowledge of tissue tropism in Trypanosoma infections in mammals, describe potential mechanisms of tissue entry, comparatively discuss relevant findings from other parasitology fields where tissue tropism has been extensively investigated, and reflect on new questions raised by recent discoveries and their potential impact on clinical treatment and disease control strategies.

https://pubmed.ncbi.nlm.nih.gov/31088251