Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • MD-PhD Student
  • Medical Staff
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • MD-PhD Student
  • Medical Staff
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell

About

Philippe Bastin grew up in the Belgian countryside where he developed interest for life sciences. He studied biology at Namur, Louvain and Brussels where he completed his doctoral studies in 1993 at the de Duve Institute. He studied a cell surface receptor in the parasitic protist Trypanosoma brucei (responsible for sleeping sickness) and identified vaccine candidates (SmithKline Beecham award in 1991). He then moved to Manchester (UK) in 1994 as an International Wellcome trust fellow to be trained in genetics, molecular biology and advanced microscopy with Keith Gull. A major achievement was the serendipitous discovery of RNA interference in trypanosomes and its exploitation to reveal the function of an enigmatic structure in the parasite flagellum. In 2000, he got an Inserm position and set up a research team at the National Muséum of Natural History in Paris before joining the Institut Pasteur in 2005 where he created the Trypanosome Cell Biology Unit. His team is actively involved in parasite cell biology, especially the flagellum that is a central organelle for trypanosomes. They set up a tsetse fly breeding facility to monitor the full life cycle of the parasite. The team developed multiple advanced microscopy tools in collaboration with the Institut Pasteur platforms and revealed various aspects of trypanosome biology, including findings that led to reconsideration of parasite diagnosis. In 2013, Bastin led a consortium of researchers and proposed the creation of a research centre dedicated to vector-borne diseases with unique state-of-the-art facilities at the Institut Pasteur for which he acts as scientific coordinator.

Projects

Project
Ongoing
5 Members

Functional Analysis of novel centrosomal and basal body components of two human parasitic protozoa

Philippe Bastin (PI)

Centrosomes (Cs) are the main microtubule organizing centers of many eukaryotic cells with critical roles in cell division, polarity, signaling and structure. Centrioles can act as basal bodies (BB), nucleating microtubules to form cilia […]
Project
Not started
5 Members

Deciphering how cells write and read the tubulin code

Philippe Bastin (PI)

Microtubules are cytoskeletal elements that are central to cell life. Their primary components are tubulins and undergo various post-translational modifications acting as a tubulin code. Here, we wish to investigate a main modification called […]
Project
Ongoing
12 Members

Role of tubulin glutamylation in flagellum construction (TUBGLUFLA)

Philippe Bastin (PI)

Cilia and flagella are essential eukaryotic organelles composed of an evolutionary conserved structure of 9 doublet microtubules that are similar but not equivalent. We propose that a tubulin post-translational modification called glutamylation could act […]
Project
Completed
2 Members

Centrosome dissection of T. gondii

Philippe Bastin (PI)

We propose to focus on deciphering the mechanistic underpinnings of intracellular replication, as a prominent source of pathogenesis. In particular, given its fundamental role in orchestrating central events to apicomplexan cell division, and flagellar […]
Project
Completed
2 Members

Molecular bases for the role of IFT172 in ciliogenesis and in ciliopathy

Philippe Bastin (PI)

The cilium is an important organelle for motility and cellular signaling found on most mammalian cells and on single celled organisms such as the parasite Trypanosoma brucei. Cilia formation requires the process of Intraflagellar […]
Project
Completed
3 Members

Mode of action of intraflagellar transport

Philippe Bastin (PI)

Cilia and flagella are found at the surface of most cells of the human body. Their malfunctioning results in ciliopathies, genetic diseases that affect 1 individual out of 400. Their construction relies on intraflagellar […]
Project
Completed
2 Members

Symposium ‘Parasitology in the 21st century’

Philippe Bastin (PI)

An exciting symposium will be organised at the Institut Pasteur on 23rd and 24th November 2015. Web site
Project
ongoing
1 Member

The Paraflagellar Rod

Philippe Bastin (PI)

  This is a lattice-like structure that is unique to Euglena and Kinetoplastida protozoa (see picture above). It is tightly attached to the axoneme as only trypsin treatment can separate the two structures. It […]
Project
ongoing
1 Member

Trypanosomes

Philippe Bastin (PI)

  The trypanosome cell African trypanosomes are protozoa (unicellular organisms) belonging to the Kinetoplastida order. They are elongated cells (20-25 µm long, 3-5 µm wide), although certain variations are observed during the life cycle. […]

CV

Nationality: Belgian

Tel + 33 1 40 61 38 35 (33 1 45 68 86 27)

Email: pbastin@pasteur.fr

Web site: http://www.pasteur.fr/research/trypa
Twitter: https://twitter.com/BastinLab_Paris

EDUCATION

2005: HDR in Biomedical Sciences at University Paris-Descartes V
1993: PhD in Biological Sciences at UCL, Brussels, Belgium (La Plus Grande Distinction)
1989: Degree in Zoological Sciences at UCL, Louvain-la-Neuve, Belgium (Grande Distinction)
RESEARCH EXPERIENCE
2005-       : Director of the Trypanosome Cell Biology Unit, Institut Pasteur & INSERM U1201, Paris
Since 2006: Director of Research (INSERM)
2000-2005: Chargé de Recherche (INSERM) and Director of the ATIPE team, INSERM U565 & CNRS UMR8646, Muséum National d’Histoire Naturelle, Paris 1994-2000: Postdoctoral fellow, University of Manchester, United Kingdom (supervisor Keith Gull)
1989-1993: PhD student UCL, Brussels, Belgium (supervisors Pierre Courtoy & Fred Opperdoes)
SCIENTIFIC ACTIVITIES >80 publications, >100 invited lectures in 20 countries
Collaborations with E. Lorentzen (MPI Munich & Aarhus), S. Vaughan (Oxford Brookes), E. Sheridan (Leeds), M. Leroux (Vancouver), Z. Okten (Munich), J. Chamot-Rooke (IP), C. Janke (Orsay), M. Francia (IP Montevideo), M. Gissot (IP Lille).
Chair of the organising committee of several international conferences (Cilia 2014, >400 participants, Parasitology in the 21st Century, 180 participants, Future of Parasitology 2017 >100 participants)
Editor for Biology of the Cell, Eukaryotic Cell, Research in Microbiology
Reviewer for various journals (>200) including PNAS, JCB, JCS, MBoC, Science, Plos journals, Curr Biol etc
TEACHING ACTIVITIES Training of 10 PhD students & 13 post-docs. Of those who left the lab, about one third found positions in academia (university of research positions), one third in the private sector (pharmaceutical companies, start-ups including one CEO) and one third are doing postdocs abroad (UK, US, Germany, Switzerland)
Member or chair of jury for PhD theses (49, 10 abroad) or Habilitation/HDR (14)
2021: European Cilia summer school, Carry-le-Rouet, 17-22nd October 2021 (co-organiser)
2018: Cilia summer school, Sète, 25-28th June 2018 (co-organiser)
2013-15: Practical courses in Parasitology for the Microbiology Course at Institut Pasteur (3 days).
2004-14: Practical courses Gene Screening by RNAi at MNHN & UPMC (1 week, co-director).
2001-: Multiple invited lectures: Parasitology, Cell Biology & Genetics in Paris or abroad (15h/year)
ADMINISTRATIVE RESPONSIBILITIES and EXPERTISE
2019-   : Chair of the Labex IBEID2 project (with C. Saleh and M. Vignuzzi), consortium of 65 labs working on emerging infectious diseases
2014-   : Chair of the Vector-Borne Disease project at the Institut Pasteur

2013-   : Director of the GDR3581 CIL (consortium of 35 labs working on cilia in France)

2017-2021: Member of the Institut Pasteur Scientific Council
2016: Chair of the Microbe and Health project (task force on feasibility to develop research on infectious diseases on the Saclay campus)
2014-17: Member of the College of Scientific Advisors of the Institut Pasteur Direction
2014-2019: Member and chair of the Health and Life Science (section 2) Scientific Committee of the FNRS (Belgium)
2016-   : Expert reviewer for ERC (Junior, Mid-career, Advanced grants)
2008-   : Expert reviewer for Medical Research Council (MRC), Biological and Biotechnology Research Council (BBSRC), Wellcome Trust, etc.
AWARD and DISTINCTIONS
2022: Fondation pour la Recherche Médicale Team
2021: Honorary Christoffel Plantin award
2015: Fondation pour la Recherche Médicale Team.
2013: Pasteur-Vallery-Radot prize (Bibliothèque Nationale de France & Académie des Sciences)
2012: George Zermati prize (Fondation de France)

MAIN RECENT RESEARCH FUNDING

  • Coordinator of FRM team (335 k€, 2022-2025)
  • Partner of PTR474 (Coordinator, Maria Francia, IP Montevideo, 250 k€, 2021-2023)
  • Coordinator of ANR TUBGLUFLA (605 k€ for the consortium, 342k€ for the team, 2018-2023)
  • Founding partner of ANR-10-LABX-62-IBEID (200 k€, 2011-2019)
  • Coordinator of FRM team (256 k€, 2015-2018)
  • Coordinator of ANR-DFG 2014 (267k€, 2014-2018)
  • Partner of ACIP76-2017 (50 k€, 5 k€ for the team, 2018-2019)

Publications

Download