Timeline
Philippe Bastin
Head of Structure
12 Jun 2024
publication
LRRC56 is an IFT cargo required for assembly of the distal dynein docking complex in Trypanosoma brucei.
Read more10 Apr 2024
03 Apr 2024
03 Apr 2024
14 Feb 2024
event
DPT Parasites and Insects Vectors Extraordinary Seminar -Professor Albert DESCOTEAUX “Leishmania remodels host cell organelles”
Read more01 Aug 2023
event
DPT Parasites and Insects Vectors Extraordinary Seminar – Professor Vyacheslav YURCHENKO “Viral and bacterial endobionts of Trypanosomatidae: lessons from the “obscure” species”
Read more06 Jun 2023
04 Apr 2023
event
DPT Parasites and Insects Vectors Seminar – David PEREZ-MORGA ” Human African Trypanosomiasis evolution and cell death in Trypanosoma brucei brucei – Chapter III”
Read more01 Jan 2023
publication
Spatial confinement of Trypanosoma brucei in microfluidic traps provides a new tool to study free swimming parasites.
Read more22 Nov 2022
event
DPT Parasites and Insects Vector seminar – Mark CARRINGTON “How do trypanosome receptors for host macromolecules bind ligands and yet avoid the host immune response?”
Read more26 Oct 2022
publication
Separate To Operate: the Centriole-Free Inner Core of the Centrosome Regulates the Assembly of the Intranuclear Spindle in Toxoplasma gondii.
Read more07 Sep 2022
project
Functional Analysis of novel centrosomal and basal body components of two human parasitic protozoa
Read more25 Jul 2022
event
DPT Parasites and insects Vectors Seminar – Maria Francia “Shedding light into the big problem by taking a good look at a tiny organelle; the centrosome and cell division in Toxoplasma gondii”
Read more08 Jun 2022
31 May 2022
publication
Restriction of intraflagellar transport to some microtubule doublets: An opportunity for cilia diversification?
Read more09 Nov 2021
event
PIV deparment seminar – Isabel RODITI “The sweet and sour sides of cyclic AMP signalling in trypanosomes”
Read more27 Oct 2021
event
PIV DPT Seminar – Ariel SILBER “Proline, a “metabolic penknife” for the dangerous lifestyle of Trypanosoma cruzi “
Read more20 Sep 2021
publication
The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands.
Read more01 Sep 2021
publication
Redistribution of FLAgellar Member 8 during the trypanosome life cycle: Consequences for cell fate prediction
Read more23 Feb 2021
publication
Ultrastructural Changes of the Mitochondrion During the Life Cycle of Trypanosoma brucei.
Read more04 Jan 2021
19 Oct 2020
23 Sep 2020
publication
Intraflagellar transport during assembly of flagella of different length in Trypanosoma brucei isolated from tsetse flies.
Read more22 Jun 2020
publication
Dynamic imaging reveals surface exposure of virulent Leishmania amastigotes during pyroptosis of infected macrophages.
Read more05 Apr 2020
publication
Timing and original features of flagellum assembly in trypanosomes during development in the tsetse fly.
Read more16 Jan 2020
14 Jan 2020
event
MORNing glory: structures and roles of MORN repeat proteins from Trypanosoma, Toxoplasma, and Plasmodium – Brooke Morriswood
Read more23 Oct 2019
event
BILBO1 and the fellowship of the ring: Deciphering the composition, assembly and function of the ring of power – Mélanie Bonhivers
Read more14 May 2019
30 Apr 2019
02 Apr 2019
publication
Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly
Read more25 Mar 2019
14 Feb 2019
01 Feb 2019
03 Dec 2018
publication
Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum.
Read more12 Nov 2018
01 Nov 2018
publication
Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects
Read more10 Oct 2018
24 Aug 2018
25 Feb 2018
14 Dec 2017
16 Nov 2017
publication
Flagellar incorporation of proteins follows at least two different routes in trypanosomes
Read more12 Mar 2017
publication
Preparation and Observation of Thick Biological Samples by Scanning Transmission Electron Tomography
Read more21 Dec 2016
01 Aug 2016
publication
Intraflagellar transport is required for the maintenance of the trypanosome flagellum composition but not its length
Read more21 Apr 2016
14 Mar 2016
05 Feb 2016
05 Feb 2016
08 Dec 2015
30 Nov 2015
19 Oct 2015
15 Oct 2015
25 Sep 2015
15 Sep 2015
14 Aug 2015
14 Aug 2015
publication
IFT81, encoding an IFT-B core protein, as a very rare cause of a ciliopathy phenotype
Read more28 Jul 2015
publication
The Flagellar Arginine Kinase in Trypanosoma brucei Is Important for Infection in Tsetse Flies
Read more10 Jul 2015
08 Jul 2015
03 Jul 2015
29 May 2015
publication
Scanning transmission electron microscopy through-focal tilt-series on biological specimens
Read more11 May 2015
31 Mar 2015
publication
The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies
Read more08 Jan 2015
01 Jan 2015
31 Dec 2014
publication
Generation of a nanobody targeting the paraflagellar rod protein of trypanosomes
Read more10 Nov 2014
02 Jul 2014
publication
The intraflagellar transport dynein complex of trypanosomes is made of a heterodimer of dynein heavy chains and of light and intermediate chains of distinct functions
Read more23 May 2014
publication
The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status
Read more24 Apr 2014
publication
The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport
Read more16 Apr 2014
publication
Proteomic analysis of intact flagella of procyclic Trypanosoma brucei cells identifies novel flagellar proteins with unique sub-localization and dynamics
Read more18 Mar 2014
29 Nov 2013
publication
Getting to the heart of intraflagellar transport using Trypanosoma and Chlamydomonas models: the strength is in their differences
Read more13 Nov 2013
publication
More than meets the eye: understanding Trypanosoma brucei morphology in the tsetse
Read more05 Nov 2013
25 Oct 2013
publication
Flagellar adhesion in Trypanosoma brucei relies on interactions between different skeletal structures in the flagellum and cell body
Read more30 Aug 2013
21 Dec 2012
publication
Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani.
Read more26 Oct 2012
publication
Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms
Read more19 Sep 2012
04 Apr 2012
publication
A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly
Read more27 Mar 2012
publication
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions
Read more30 Sep 2011
publication
ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation
Read more26 Apr 2011
publication
Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation
Read more19 Apr 2011
01 Mar 2011
01 Mar 2011
18 Jan 2011
publication
Molecular bases of cytoskeleton plasticity during the Trypanosoma brucei parasite cycle
Read more29 Jun 2010
publication
Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.
Read more25 Jun 2010
27 Apr 2010
publication
The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia
Read more04 Dec 2009
01 Dec 2009
publication
Loss-of-function mutations in the human ortholog of Chlamydomonas reinhardtii ODA7 disrupt dynein arm assembly and cause primary ciliary dyskinesia
Read more23 Nov 2009
publication
Kinesin 9 family members perform separate functions in the trypanosome flagellum
Read more24 Feb 2009
publication
A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum
Read more04 Feb 2009
publication
The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?
Read more21 Oct 2008
publication
Flagellum elongation is required for correct structure, orientation and function of the flagellar pocket in Trypanosoma brucei
Read more19 Dec 2007
publication
Intraflagellar transport and functional analysis of genes required for flagellum formation in trypanosomes
Read more01 Aug 2007
publication
The Argonaute protein TbAGO1 contributes to large and mini-chromosome segregation and is required for control of RIME retroposons and RHS pseudogene-associated transcripts
Read more09 May 2007
publication
Basal body positioning is controlled by flagellum formation in Trypanosoma brucei
Read more01 Aug 2006
publication
Conserved and specific functions of axoneme components in trypanosome motility
Read more09 Feb 2005
01 Jan 2005
12 Dec 2003
publication
TbAGO1, an argonaute protein required for RNA interference, is involved in mitosis and chromosome segregation in Trypanosoma brucei
Read more15 Oct 2003
publication
Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes
Read more01 Jun 2003
publication
Efficiency and specificity of RNA interference generated by intra- and intermolecular double stranded RNA in Trypanosoma brucei
Read more01 Jan 2003
01 Mar 2001
01 Dec 2000
01 Sep 2000
publication
Flagellum ontogeny in trypanosomes studied via an inherited and regulated RNA interference system
Read more01 Dec 1999
publication
Flagellar morphogenesis: protein targeting and assembly in the paraflagellar rod of trypanosomes
Read more01 Nov 1999
publication
Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1
Read more01 Aug 1999
publication
Assembly and function of complex flagellar structures illustrated by the paraflagellar rod of trypanosomes
Read more01 Feb 1998
01 Dec 1997
publication
A motility function for the paraflagellar rod of Leishmania parasites revealed by PFR-2 gene knockouts
Read more01 Aug 1996
01 May 1996
publication
A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei
Read more01 Feb 1996
publication
An M(r) 145,000 low-density lipoprotein (LDL)-binding protein is conserved throughout the Kinetoplastida order
Read more01 Jan 1995
publication
Activity, pharmacological inhibition and biological regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Trypanosoma brucei
Read more01 Feb 1994
publication
Identification of a specific epitope on the extracellular domain of the LDL-receptor of Trypanosoma brucei brucei
Read more01 Feb 1992
publication
Trypanosoma brucei brucei: antigenic stability of its LDL receptor and immunological cross-reactivity with the LDL receptor of the mammalian host
Read more15 Jul 1991
publication