Tissue and Cell Homeostasis
Eukaryotic cells contain extensive internal membranes defining many compartments having each specific functions. However these organelles are constantly moving and reshaping, still retaining their identity. The maintenance of cell compartmentalization in eukaryotes is thus very complex and tightly controlled.
Our team deals with intracellular trafficking of eukaryotic cells and how it regulates cell and tissue organization. In particular we study endocytosis and exocytosis pathways and their linked to lipid distribution, cell compartmentalization and host-pathogen interactions.
More recently my group focuses on human intestinal homeostasis under physiological and pathological conditions, such as inflammation or infection. Our goal is to understand how the complex environment of the human intestine, organized in 3D, constantly subjected to mechanical forces and in close relationship with the microbiota and immune cells, enables its highly dynamic regeneration and can be hijacked by numerous pathogens. The topics of my group include cell biology, stem cells, cell differentiation, mechanobiology, infectious diseases, microbiota, inflammation and innate immunity.
For this purpose we used an array of techniques from high resolution microscopy, single molecules tracking, robust image analysis, statistical classification, crispR-cas9 edition, organoid to organ-on-a-chip.
