Nathalie Sauvonnet

Impact of microbiota on spatial gene expression along the 3D colonic barrier Spatial organization at the cellular level is a fundamental aspect of complex life, orchestrating intricate biological processes with remarkable precision. This organization […]

Inflammatory bowel disease (IBD) is a multifactorial pathology characterized by impairment of the intestinal barrier and an excessive immune response to gut microbiota. The QUOBII project aims to explore the role of bacterial quorum […]

FLAMCHIP est une demande d’utilisation à des fins scientifiques de données et d’échantillons collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif de FLAMCHIP ? L’objectif est de mettre au point une […]

Mechanical forces trigger many cellular functions and change the geometry and physical properties of a tissue. Very few studies look at the biomechanisms of invasion of microbes at tissue level. – In this project […]

To understand protein functions and molecular network organisation, it is important to determine the localisation of proteins at subcellular level. The in cellulo probing of molecular assemblies is usually performed with microscopy techniques which […]

The intestine, and in particular the colon, comprising a mucus blanket, an epithelial monolayer and the lamina propria rich in immune cells, is constantly subjected to shear stress (flow) and peristaltic motion (stretching), both […]

The goal of this project is to develop a new organ-on-chip microfluidic device based on the actuation of thin hydrogel layers. Indeed, hydrogels possess interesting properties, compared to the commonly used perforated PDMS membranes. […]

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]

Endocytosis is an essential process used to internalize a wide range of molecules, and involved in many processes such as cell migration, cell division, immunity and pathogen invasion. Several endocytic pathways exist, enabling the […]

The distribution of cholesterol – in a gradient – is essential for compartments organization. Cholesterol distribution within the organelles should be tightly controlled but so far little is known on the dynamics its intracellular […]

Welcome to the club! Welcome to Microfluidics@Pasteur! Our goal is to serve as the major entry point to all the scientists on the campus (beginners and experts) interested in undertaking projects where microfluidics is involved. Our […]