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© Institut Pasteur
Structure cristalline de l'hémophore HasA de Serratia marcescens. Les hélices alpha sont colorées en rouge et les brins bêta en bleu. La molécule d'héme est colorée en jaune et les chaînes latérales des acides aminés ligands de l'hème sont colorées en vert.

Events

William Clemons seminar

Séminaire du Département de Biologie Structurale & Chimie Lundi 29 mai 2017 à 14h00 Salle LWOFF 14 – RDC 22  Prof. William Clemons Caltech, Pasadena Structural Insights into the Targeting of Tail-Anchored Membrane Proteins […]

2017-05-29 14:00:00 2017-05-29 18:00:00 Europe/London William Clemons seminar Séminaire du Département de Biologie Structurale & Chimie Lundi 29 mai 2017 à 14h00 Salle LWOFF 14 – RDC 22  Prof. William Clemons Caltech, Pasadena Structural Insights into the Targeting of Tail-Anchored Membrane Proteins […] 28 Rue du Dr Roux, Paris, France

Projects

CV

Born 1952, Directeur de Recherche Classe Exceptionnelle DRCE CNRS and Chef de Laboratoire at the Institut Pasteur

Muriel DELEPIERRE studied chemistry is graduated from Ecole Nationale Supérieure de Chimie de Clermont-Ferrand and has obtained a doctor engenier thesis on the study of mononucleotide in solution by NMR (1979) and then a PhD thesis in Physics and Chemistry (1983 Orsay) for work achieved both at Harvard university and Oxford university on structure and dynamics of lysozyme in solution by NMR. Muriel Delepierre is working on solution structure of biological molecules as well as the study of their interaction in relation to their function. The driving force, is to adapt NMR techniques to biological problems. How can NMR be used to answer a given biological question and is NMR the only tool that can be used? Thus, both state of the art NMR techniques and different biophysical approaches are employed

Research activities

(1979-1980) Researcher at Harvard University, Cambridge USA (Christopher Dobson); (1980-1982) Researcher at Oxford University, Oxford UK (Christopher Dobson); 1983 PhD and Habilitation Université Paris-Sud; (1983-1989) CR1 at Pharmaceutical school Paris V leader of the NMR lab (Pr Bernard Roques); since 1989 head of the NMR laboratory and then of the Unité de RMN des Biomolécules at the Institut Pasteur.

Administrative positions 2004-2012 Director of URA 2185 “Biologie Structurale des agents Infectieux”; From 2010-2014 Director de l’Evaluation des Cadres de Recherche at the Institut Pasteur. Since 2015 chargée de mission pour la chimie

Member of Scientific Societies: SFET, SFB, SFBBM.

Supervision: 6 PhD students, codirection of 6 PhD students 2 Post-docs,

Publications: 159 primary including reviews and 9 book chapters or conference proceedings, 1monography book with Joël Janin “Biologie Structurale: principes et méthodes biophysiques” 1997 (in French)

Referees for: Biochemistry, European Journal of Biochemistry, Journal of Molecular Biology, Magnetic Resonance in Chemistry, Journal of Magnetic Resonance, Journal of Physical Chemistry, Protein Science, Nucleic Acid Research, Journal of American Chemical Society,Biophysical Journal, but also for various grant applications : projects fo Région Rhône Alpe 2000, 2002 , 2007 and for Région Centre Auvergne Limousin 2003 2007; Region Aquitaine, appel d’offres Ministère « Biologie Cellulaire Moléculaire et Structurale; ANR 2006, 2007.

Evaluator of 56 thesis and 14 Habilitations (HDR) and board member of 14 thesis

Services to the scientific community: Member of various committee: nominated at Committee national du CNRS section 21 (2000 à 2004); at bureau and council of Department de Biologie Structurale et Chimie Institut Pasteur (since 2001). Member of the Institut Pasteur 2004-2006 evaluation committee and then President of the same committee from 2006 to 2008. Nominated at commission CS8 of l’ANR 2008-2009 and then CSS32 in 2015 as vice-president. President of the “Comité National de Biophysique” since 2010. Teaching: biophyscis at the master level (Biological NMR) since 1985

Organization. Since 2000 together with Anne Lecroisey we have organized 8 international conferences NMR a tool for biology. We have organized the last International Conference of Biological NMR in Lyon, (the XXVth ICMRBS). This conference gathered 850 attendees. EUROMAR Board from 2008-2013. EuCHEMS Chemistry for Life Science French representant since 2008.

Honors: Médaille de bronze du CNRS (1989), Prix Thérèse Lebrasseur Fondation de France (1997), Chevalier de l’Ordre National du Mérite 2007, Chevalier de la Légion d’Honneur 2013.

Publications