Marcel Hollenstein, hailing from Lutry (Switzerland), studied chemistry at the University of Lausanne (Switzerland) where he obtained a diploma in 1999. He then moved to the group led by Prof. Christian Leumann at the University of Bern (Switzerland) for his PhD, obtained in 2004. During his PhD, he synthesized fluorinated peptide nucleic acids (PNA) with the aim of investigating structural key features of these important DNA analogs. In 2005, he moved to the group of Prof. David Perrin at the University of British Columbia (Vancouver, Canada) for a postdoctoral stay. During this time, he was involved in Darwinian selection experiments (SELEX) to generate chemically modified DNA enzymes capable of cleaving RNA targets in the absence of divalent metal co-factors. In 2009, Marcel moved back to Bern (in the group of Prof. Christian Leumann) with a grant from the Swiss National Science Foundation (Ambizione fellowship) to work on independent research projects that dealt with the synthesis and biochemical characterization of modified nucleoside triphosphates for their futher use in the development of aptamers, DNA enzymes, and bionanomaterials. In January 2016, he was offered a position at the Institut Pasteur (Paris, France) to lead a 5-year junior group ‘bioorganic chemistry of nucleic acids’ in the department of structural biology and chemistry.
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2025Enzymatic synthesis of RNA oligonucleotides, Nat. Biotechnol. 2025, 43, 691-693.
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2025Natural, modified and conjugated carbohydratesin nucleic acids, Chem. Soc. Rev. 2025, 54, 2948-2983.
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2025Crystal structures of monomeric BsmI restriction endonuclease reveal coordinated sequential cleavage of two DNA strands, Communications Biology, 2025, 8 (1), pp.387. ⟨10.1038/S42003-025-07612-Z⟩.
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2025Recent Advances in Biocatalytic and Chemoenzymatic Synthesis of Oligonucleotides, ChemBioChem. 2025, 26, e202400987.
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2024Template-dependent DNA ligation for the synthesis of modified oligonucleotides., Nat. Commun. 2024, 15, 8009.
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2024Template-dependent DNA ligation for the synthesis of modified oligonucleotides., Nat Commun 2024 Sep; 15(1): 8009.
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2024A toolbox for enzymatic modification of nucleic acids with photosensitizers for photodynamic therapy, RSC Chem. Biol. 2024, 5, 841-852.
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2024Controlled enzymatic synthesis of oligonucleotides, Commun. Chem. 2024, 7, 138.
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2023Expedient synthesis of l-heptose derived septacidin building blocks from l-glucose, Carbohydr. Res. 2023, 534, 108985.
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2023Artificial nucleotide codons for enzymatic DNA synthesis, Chem. Commun., 2023,59, 14547-14550.
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