Marcel Hollenstein, hailing from Lutry (Switzerland), studied chemistry at the University of Lausanne (Switzerland) where he obtained a diploma in 1999. He then moved to the group led by Prof. Christian Leumann at the University of Bern (Switzerland) for his PhD, obtained in 2004. During his PhD, he synthesized fluorinated peptide nucleic acids (PNA) with the aim of investigating structural key features of these important DNA analogs. In 2005, he moved to the group of Prof. David Perrin at the University of British Columbia (Vancouver, Canada) for a postdoctoral stay. During this time, he was involved in Darwinian selection experiments (SELEX) to generate chemically modified DNA enzymes capable of cleaving RNA targets in the absence of divalent metal co-factors. In 2009, Marcel moved back to Bern (in the group of Prof. Christian Leumann) with a grant from the Swiss National Science Foundation (Ambizione fellowship) to work on independent research projects that dealt with the synthesis and biochemical characterization of modified nucleoside triphosphates for their futher use in the development of aptamers, DNA enzymes, and bionanomaterials. In January 2016, he was offered a position at the Institut Pasteur (Paris, France) to lead a 5-year junior group ‘bioorganic chemistry of nucleic acids’ in the department of structural biology and chemistry.
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2023Controlled E. coli Aggregation Mediated by DNA and XNA Hybridization, ChemBioChem 2023, 24, e202300191.
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2023Towards the controlled enzymatic synthesis of LNA containing oligonucleotides., Front Chem 2023 ; 11(): 1161462.
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2022Enzymatic Synthesis of Vancomycin-Modified DNA, Molecules 2022, 27, 8927.
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2022High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis, Cells 2022, 11(23), 3862.
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2022Ferrocene as a potential electrochemical reporting surrogate of abasic sites in DNA, Org. Biomol. Chem., 2022, 20, 8125 - 8135.
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2022Chemical Modifications for a Next Generation of Nucleic Acid Aptamers, ChemBioChem 2022, 23, e202200006.
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2022Benzoyl and pivaloyl as efficient protecting groups for controlled enzymatic synthesis of DNA and XNA oligonucleotides, Asian J. Org. Chem. 2022, e202200384.
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2022Evaluation of 3′-phosphate as a transient protecting group for controlled enzymatic synthesis of DNA and XNA oligonucleotides, Commun. Chem. 2022, 5, 68.
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2022Evaluation of 3′-phosphate as a transient protecting group for controlled enzymatic synthesis of DNA and XNA oligonucleotides., Commun Chem 2022 Jun; 5(1): 68.
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2022Towards polymerase-mediated synthesis of artificial RNA–DNA metal base pairs, New J. Chem., 2022, 46, 4871-4876.
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