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© Marie-Christine Prévost, Anne Derbise
Bactéries Yersinia pestis en microscopie electronique à balayage.
Publication : Microbes and infection

Staphylococcus aureus NAD kinase is required for envelop and antibiotic stress responses.

Team: Yersinia
Team: UMR6047 – Integrative and Molecular Microbiology
Member: Clarisse Leseigneur
Member: Lou Mondange
Member: Javier Pizarro-Cerda
Member: Olivier Dussurget
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbes and infection - 30 Mar 2024

Leseigneur C, Mondange L, Pizarro-Cerdá J, Dussurget O

Link to Pubmed [PMID] – 38556158

Link to DOI – 10.1016/j.micinf.2024.105334

Microbes Infect 2024 Mar; (): 105334

Global burden of infectious diseases and antimicrobial resistance are major public health issues calling for innovative control measures. Bacterial NAD kinase (NADK) is a crucial enzyme for production of NADP(H) and growth. In Staphylococcus aureus, NADK promotes pathogenesis by supporting production of key virulence determinants. Here, we find that knockdown of NADK by CRISPR interference sensitizes S. aureus to osmotic stress and to stresses induced by antibiotics targeting the envelop as well as replication, transcription and translation. Thus, NADK represents a promising target for the development of inhibitors which could be used in combination with current antibiotics.