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Javier Pizarro-Cerda obtained B.Sc. and M.Sc. degrees from the University of Costa Rica while working in the laboratory of Edgardo Moreno, studying the adaptations of the outer membrane of the Gram-negative pathogen Brucella abortus to cationic peptides. He then obtained a D.E.A. and a Ph.D. from the University of Aix-Marseilles while working in the laboratory of Jean-Pierre Gorvel, identifying the intracellular trafficking of Brucella abortus in epithelial cells. Subsequently, he joined the laboratory of Pascale Cossart at the Pasteur Institute in Paris to investigate signaling cascades triggered by the Gram-positive pathogen Listeria monocytogenes during invasion of host mammalian cells. In 2001 Javier Pizarro-Cerda joins the Pasteur Institute as a permanent researcher and obtains his first grant from the French Ministry of Research. Since, he has been involved in local (Pasteur Institute Transversal Programs), national (National Agency for Research) and international (ERANET, System X) research initiatives, investigating the adaptations of bacterial pathogens to intracellular life. He has been actively involved in teaching and has participated in practical and theoretical courses in France, Argentina, Costa Rica, Grèce and China. During his career, Javier Pizarro-Cerda has developed his research as invited investigator in different international laboratories including the Center for Microscopy & Microanalysis (Queensland University, Australia), the Weizmann Institute (Rehovot, Israel), the University of Texas-Southwestern (Dallas, USA), the Max Planck Institute for Infection Biology (Berlin, Germany) and the Biozentrum (Basel, Switzerland). In 1998, Javier Pizarro-Cerda obtains the Costarrican National Award for Science ‘Clodomiro Picado-Twight’, in 2012 he becomes member of the Costarrican Academy of Sciences and in 2015 he receives the Senate Medal from the French Senate for his contribution fostering interactions between France and Latin America. In 2016, Javier Pizarro-Cerda becomes head of the ‘Systems Biology of Bacterial Infections Group’ and is promoted as Director of Research from the Pasteur Institute.
Publications
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2018Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine, Vaccine 2018 Nov;.
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2018Listeriolysin O-dependent host surfaceome remodeling modulates Listeria monocytogenes invasion, Pathog Dis 2018 Nov;76(8).
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2018Listeria monocytogenes: cell biology of invasion and intracellular growth, Microbiol Spectr 2018 Nov;6(6).
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2018Reassessing the role of Internalin B in Listeria monocytogenes virulence using the epidemic strain F2365, Clin. Microbiol. Infect. 2018 Sep;.
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2018First isolation of Yersinia entomophaga in human urinary tract, New Microbes New Infect 2018 Nov;26:3-7.
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2018Isolation of a Yersinia enterocolitica biotype 1B strain in France, and evaluation of its genetic relatedness to other European and North American biotype 1B strains, Emerg Microbes Infect 2018 Jul;7(1):121.
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2018Role in virulence of phospholipases, listeriolysin O and listeriolysin S from epidemic Listeria monocytogenes using the chicken embryo infection model, Vet. Res. 2018 02;49(1):13.
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2018Listeria costaricensis sp. nov, Int. J. Syst. Evol. Microbiol. 2018 Mar;68(3):844-850.
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2017Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles, Nat Commun 2017 11;8(1):1396.
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2017Listeriolysin S Is a Streptolysin S-Like Virulence Factor That Targets Exclusively Prokaryotic Cells In Vivo, MBio 2017 Apr;8(2).
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