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Viral Pathogenesis Unit’s Project
Lisa Chakrabarti (PI)
Research in the Viral Pathogenesis Unit focuses on (i) the pharmacological, biological, and physiopathological study of chemokines and chemoreceptors, with an emphasis on CXCR4 and CCR5, the two major coreceptors for HIV entry; (ii) […]
2018CCR5 structural plasticity shapes HIV-1 phenotypic properties, PLoS Pathog. 2018 Dec;14(12):e1007432.
2016Guidelines for cloning, expression, purification and functional characterization of primary HIV-1 envelope glycoproteins, J. Virol. Methods 2016 Oct;236:184-95.
2015A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity, Retrovirology 2015;12:50.
2014Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry, J. Biol. Chem. 2014 Jul;289(27):19042-52.
2013HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines, Proc. Natl. Acad. Sci. U.S.A. 2013 Jun;110(23):9475-80.
2012Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody, Structure 2012 Feb;20(2):303-14.
2010New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection, J. Biol. Chem. 2011 Feb;286(7):4978-90.
2008The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins, PLoS ONE 2008;3(7):e2543.
2007The C type lectins DC-SIGN and L-SIGN: receptors for viral glycoproteins, Methods Mol. Biol. 2007;379:51-68.
2006Infection of dendritic cells (DCs), not DC-SIGN-mediated internalization of human immunodeficiency virus, is required for long-term transfer of virus to T cells, J. Virol. 2006 Mar;80(6):2949-57.
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