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Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome
Nicolas Wolff (PI)
Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]
Rabies virus neuronal infection
Nicolas Wolff (PI)
We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]
Role of PDZ-binding motif from Flavivirus non-structural proteins in flaviviral life cycle
Nathalie Pardigon (PI)
Arthropod-borne viruses (arboviruses) include numerous human and animal pathogens that are important global health threats. Flaviviruses are arboviruses belonging to the Flaviviridae family. They include neurotropic viruses such as West Nile (WNV), Japanese encephalitis […]
I did my Master and my PhD in the NMR unit of Biomolecules headed by Mrs. Delepierre at the Institut Pasteur. My thesis focused on the study of heme acquisition mechanism in bacteria. I used biophysical approaches, mainly nuclear magnetic resonance (NMR). I joined for my post-doc the team of biocrystallography led by Stéphane Bressanelli in the Molecular and Structural Virology Unit directed by Yves Gaudin (Gif-sur-Yvette). My project focused on the study of genome replication of hepatitis C virus (HCV). I acquired a dual expertise in NMR and X-ray crystallography. Then I joined the team of Nicolas Wolff. I worked mainly on the human phosphatases PTPN4 and PTPN3. More generally, I am interested in the signaling pathways of the cell involving PDZ-containing proteins.
Our group joined the Channel Receptors Unit since 2018 led by Pierre-Jean Corringer (Department of Neuroscience). The Unit is interested by the pentameric ligand-gated ion channels (pLGICs). This superfamily of membrane proteins are involved in particular in the neuronal communication.
2019Identification of protein-protein and ribonucleoprotein complexes containing Hfq, Sci Rep 2019 Oct;9(1):14054.
2019Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein, Sci Rep 2019 May;9(1):7438.
2017Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains, Sci Rep 2017 Aug;7(1):7875.
2016Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ, J. Biol. Chem. 2016 08;291(32):16699-708.
2015Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus, Prog. Biophys. Mol. Biol. 2015 Oct;119(1):53-9.
2014Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development, Antiviral Res. 2014 May;105:8-16.
2012Role of the iron axial ligands of heme carrier HasA in heme uptake and release, J. Biol. Chem. 2012 Aug;287(32):26932-43.
2012Two crucial early steps in RNA synthesis by the hepatitis C virus polymerase involve a dual role of residue 405, J. Virol. 2012 Jul;86(13):7107-17.
2011An objective assessment of conformational variability in complexes of hepatitis C virus polymerase with non-nucleoside inhibitors, J. Mol. Biol. 2011 Dec;414(3):370-84.
2011Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations, Hepatology 2011 Oct;54(4):1157-66.
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