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Biochimie des Protéines
La biochimie des protéines est une discipline sans cesse dynamisée par l’émergence de nouvelles technologies à la convergence de la chimie, la biophysique, la biologie moléculaire et la biologie cellulaire. Elle regroupe les méthodes […]
2021-01-11 09:00:00 2021-02-12 18:00:00 Europe/Paris Biochimie des Protéines La biochimie des protéines est une discipline sans cesse dynamisée par l’émergence de nouvelles technologies à la convergence de la chimie, la biophysique, la biologie moléculaire et la biologie cellulaire. Elle regroupe les méthodes […] 28 Rue du Docteur Roux, Paris, France
Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)
Nicolas Wolff (PI)
Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular […]
Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome
Nicolas Wolff (PI)
Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]
Rabies virus neuronal infection
Nicolas Wolff (PI)
We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]
Role of PDZ-binding motif from Flavivirus non-structural proteins in flaviviral life cycle
Nathalie Pardigon (PI)
Arthropod-borne viruses (arboviruses) include numerous human and animal pathogens that are important global health threats. Flaviviruses are arboviruses belonging to the Flaviviridae family. They include neurotropic viruses such as West Nile (WNV), Japanese encephalitis […]
I did my Master and my PhD in the NMR unit of Biomolecules headed by Mrs. Delepierre at the Institut Pasteur. My thesis focused on the study of heme acquisition mechanism in bacteria. I used biophysical approaches, mainly nuclear magnetic resonance (NMR). I joined for my post-doc the team of biocrystallography led by Stéphane Bressanelli in the Molecular and Structural Virology Unit directed by Yves Gaudin (Gif-sur-Yvette). My project focused on the study of genome replication of hepatitis C virus (HCV). I acquired a dual expertise in NMR and X-ray crystallography. Then I joined the team of Nicolas Wolff. I worked mainly on the human phosphatases PTPN4 and PTPN3. More generally, I am interested in the signaling pathways of the cell involving PDZ-containing proteins.
Our group joined the Channel Receptors Unit since 2018 led by Pierre-Jean Corringer (Department of Neuroscience). The Unit is interested by the pentameric ligand-gated ion channels (pLGICs). This superfamily of membrane proteins are involved in particular in the neuronal communication.
2021Role of PDZ-binding motif from West Nile virus NS5 protein on viral replication., Sci Rep 2021 Feb; 11(1): 3266.
2021Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein., Sci Rep 2021 Jan; 11(1): 944.
2020Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners., J Mol Biol 2020 Nov; 432(22): 5920-5937.
2020Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study., Structure 2020 07; 28(7): 747-759.e3.
2020Interactomic affinity profiling by holdup assay: Acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase., PLoS One 2020 ; 15(12): e0244613.
2019Identification of protein-protein and ribonucleoprotein complexes containing Hfq., Sci Rep 2019 Oct; 9(1): 14054.
2019Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein., Sci Rep 2019 05; 9(1): 7438.
2017Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains., Sci Rep 2017 08; 7(1): 7875.
2016Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ., J Biol Chem 2016 08; 291(32): 16699-708.
2015Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus., Prog Biophys Mol Biol 2015 Oct; 119(1): 53-9.
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