Désolé, cet article est seulement disponible en Anglais Américain.
Cliquez pour voir le graph
Connexions
Cliquez pour voir la ligne de temps
Ligne de temps
Cours
Biochimie des Protéines
La biochimie des protéines est une discipline sans cesse dynamisée par l’émergence de nouvelles technologies à la convergence de la chimie, la biophysique, la biologie moléculaire et la biologie cellulaire. Elle regroupe les méthodes […]
2021-01-11 09:00:00
2021-02-12 18:00:00
Europe/Paris
Biochimie des Protéines
La biochimie des protéines est une discipline sans cesse dynamisée par l’émergence de nouvelles technologies à la convergence de la chimie, la biophysique, la biologie moléculaire et la biologie cellulaire. Elle regroupe les méthodes […]
28 Rue du Docteur Roux, Paris, France
Projets
CV
I did my Master and my PhD in the NMR unit of Biomolecules headed by Mrs. Delepierre at the Institut Pasteur. My thesis focused on the study of heme acquisition mechanism in bacteria. I used biophysical approaches, mainly nuclear magnetic resonance (NMR). I joined for my post-doc the team of biocrystallography led by Stéphane Bressanelli in the Molecular and Structural Virology Unit directed by Yves Gaudin (Gif-sur-Yvette). My project focused on the study of genome replication of hepatitis C virus (HCV). I acquired a dual expertise in NMR and X-ray crystallography. Then I joined the team of Nicolas Wolff. I worked mainly on the human phosphatases PTPN4 and PTPN3. More generally, I am interested in the signaling pathways of the cell involving PDZ-containing proteins.
Our group joined the Channel Receptors Unit since 2018 led by Pierre-Jean Corringer (Department of Neuroscience). The Unit is interested by the pentameric ligand-gated ion channels (pLGICs). This superfamily of membrane proteins are involved in particular in the neuronal communication.
Publications
Télécharger-
2020Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners., 2020 Sep; (): .
-
2020Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study, Structure 2020 Apr;.
-
2019Identification of protein-protein and ribonucleoprotein complexes containing Hfq, Sci Rep 2019 Oct;9(1):14054.
-
2019Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein., Sci Rep 2019 05; 9(1): 7438.
-
2017Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains, Sci Rep 2017 Aug;7(1):7875.
-
2016Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ, J. Biol. Chem. 2016 08;291(32):16699-708.
-
2015Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus, Prog. Biophys. Mol. Biol. 2015 Oct;119(1):53-9.
-
2014Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain, FEBS J. 2014 Nov;281(21):4852-65.
-
2014Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development, Antiviral Res. 2014 May;105:8-16.
-
2012Role of the iron axial ligands of heme carrier HasA in heme uptake and release, J. Biol. Chem. 2012 Aug;287(32):26932-43.
-
+Voir la liste complète de publications