Dr Sáez-Cirión received his PhD in Science in 2001 from the University of the Basque Country, Leioa, Spain. He joined the Institut Pasteur in Paris as a Postdoc in 2003 after a first postdoctoral period at the FDA-CBER in Bethesda. He leads now the Viral Reservoirs and Immune Control Unit. His research is currently focused in understanding (i) the mechanisms underlying control of HIV infection in natural HIV controllers and post-treatment controllers in remission of HIV infection after interruption of antiretroviral treatment; (ii) the factors associated with the establishment of HIV reservoirs and devising new approaches to tackle them.
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About
Courses
HIV Science MOOC
In this MOOC we will review different aspects of HIV infection: from its biological origin and its identification as the causative agent of AIDS to the perspectives of eradication. >>Register here<< In this MOOC […]
2023-11-14 09:00:00
2024-01-31 22:00:00
Europe/Paris
HIV Science MOOC
In this MOOC we will review different aspects of HIV infection: from its biological origin and its identification as the causative agent of AIDS to the perspectives of eradication. >>Register here<< In this MOOC […]
Projects
Former Teams
CV
RESEARCH POSITIONS
| 2023-current | Associate Professor and Head of the Viral Reservoirs and Immune Control Unit, Institut Pasteur, Paris, France. |
| 2018-2022 | Associate Professor and Team Leader in the Unité HIV inflammation et persistance, Institut Pasteur, Paris, France. |
| 2014-2017 | Assistant Professor and Team Leader in the Unité HIV inflammation et persistance, Institut Pasteur, Paris, France. |
| 2010-2014 | Assistant Professor in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. |
| 2007-2009 | Senior Scientist in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. |
| 2003-2007 | Postdoctoral position in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. Research advisor: Dr. Gianfranco Pancino. Project: Mechanism of resistance to HIV-1 infection in human primary cells. |
| 2002-2003 | Postdoctoral position in the Division of Viral Products, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Bethesda MD, USA. Research advisor: Dr. Carol D. Weiss. Project: Rational approaches to block HIV entry. |
| 1998-2001 | PhD student in the Unidad de Biofisica (CSIC-UPV/EHU), Department of Biochemistry, University of the Basque Country, Leioa, Spain. Research advisor: Prof. J.L. Nieva. Project: Mechanisms of virus-induced membrane fusion. |
| 1995-1998 | Undergraduate Student in the Unidad de Biofísica (CSIC-UPV/EHU), University of the Basque Country, Leioa, Spain. Research advisors: Prof. A. Alonso and Prof. E. A. Rivas. Projects: Effects of lipids in membrane fusion and Effects of surfactants in the different phases of lipids on model membranes. |
ACADEMIC QUALIFICATION
| 2013 | HDR in Life Sciences, Université Pierre et Marie Curie, Paris VI, Paris, France. |
| 2001 | PhD in Biochemistry and Molecular Biology, University of the Basque Country, Leioa, Spain. “Membrane interacting domains in virus and prions”. Suma Cum Laude. |
| 2000 | MSc degree, in Biochemistry. University of the Basque Country, Leioa, Spain. |
| 1998 | Graduated in Biochemistry, University of the Basque Country, Leioa, Spain. |
SOME ADDITIONAL PROFESSIONAL RESPONSABILITIES
| 2017-present | President of Scientific and Medical Committee of SIDACTION | ||
| 2014-present | Coordinator of the ANRS RHIVIERA consortium on HIV remission | ||
| 2013-present | Coordinator of the ANRS International Post-Treatment Controllers cohort | ||
| 2013-present | Member of the Scientific and Medical Committee of SIDACTION | ||
| 2012-present | Member of the Scientific Committee of CO6 ANRS PRIMO cohort | ||
| 2012-present | Member of Institut Pasteur’s Groupe de Réflexion sur le SIDA (GRS) | ||
| 2012-present | Member of the Steering Committee of CO21 ANRS CODEX cohort | ||
| 2011-2017 | Co-president of the ANRS coordinated action AC32 “HIV reservoirs” | ||
| 2010-2017 | Elected Member of Institut Pasteur’s Virology Department Council | ||
Publications
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2024Antiviral capacity of the early CD8 T-cell response is predictive of natural control of SIV infection: Learning in vivo dynamics using ex vivo data., PLoS Comput Biol 2024 Sep; 20(9): e1012434.
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2024Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells., Nat Med 2024 Sep; (): .
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2024Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence., Nat Immunol 2024 Jun; (): .
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2024High concentrations of Maraviroc do not alter immunological and metabolic parameters of CD4 T cells., Sci Rep 2024 Jun; 14(1): 13980.
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2024Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort: a prospective observational cohort study., Lancet HIV 2024 Jun; 11(6): e389-e405.
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2024CD8 + T-cell priming is quantitatively but not qualitatively impaired in people with HIV-1 on antiretroviral therapy., AIDS 2024 Feb; 38(2): 161-166.
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2024Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells., Nat Commun 2024 Jan; 15(1): 178.
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2023[A shot of synTac to activate CD8+ T cells cytotoxic specific response against HIV]., Med Sci (Paris) 2023 Oct; 39(10): 783-786.
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2023Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller., Cell Host Microbe 2023 Jul; (): .
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2023Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection., EBioMedicine 2023 Apr; 91(): 104557.
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