- Research Engineer
- PhD in Physics
- Expertise: Cryo-electron tomography and 3D Reconstructions, (Cryo-)CLEM approaches, Image analysis, EM automated acquisitions, 3D rendering with Amira, Widefield and Confocal fluorescent microscopy. Application of these methods to the study of eukaryotic cells, bacteria, viruses and host-pathogen interactions.
- Since 2007 Research Engineer, Ultrastructural BioImaging (UBI) Platform, Institut ____________Pasteur (Head: G. Dumenil; 2015-2019: J.Krijnse-Locker; 2007-2015: S. Shorte)
- 2014-2016 Visiting Scientist, LBME lab, Toulouse, FR ( P.-E. Gleizes)
- 2004-2007 Postdoctoral fellow, MPI of Bioch., Munich, Germany ( W. Baumeister)
- 2001-2004 Postdoctoral fellow, Institut Curie UMR168, Paris, France ( J.-L. Viovy)
- 1998- 2001 PhD in Mathematical Physics, Imperial College, London, UK ( A. Parry)
- 1995- 1996 Erasmus student, Imperial College, London, UK
- 1991- 1997 Master Degree in Physics, University of Padua, Italy ( A. Stella)
Anna is a Physicist with a strong passion for Imaging and Microscopy. After obtaining a degree in Physics at the University of Padua, Italy, and a PhD in Physics at Imperial College, London, UK, she turned towards the world of Microscopy in Life Science. She was granted a Postdoctoral Marie Curie Individual Fellowship at Institut Curie, Paris, where she focused on fluorescent videomicroscopy to model DNA migration in polymeric matrices. Then, she moved on for a second PostDoc in the cryo-EM renowned lab of Prof. W. Baumeister at the MPI of Biochemistry in Munich, where she established a novel technique, the correlation between fluorescent microscopy in cryogenic conditions and cryo-electron tomography (cryo-CLEM).
Since 2007, she works at the UBI platform as an expert of 3D cryo-electron microscopy. She is in charge of collaborative scientific projects involving high resolution cryo-tomography and (cryo-)CLEM applied to the study of host-pathogen interaction, starting from sample preparation to data collection and analysis. In one of her latest research works in collaboration with the group of Prof. C. Zurzolo at Institut Pasteur, she conceived a novel cryo-CLEM approach that uncovered for the first time the striking actin’ structural organization of Tunneling Nanotubes in neuronal cells.
She is very fond of technological/methodological development, in particular of designing novel workflows for 3D cryo-CLEM of cellular systems, including cryo-focused ion beam (cryo-FIB) and cryo-lamellae. She is also actively testing and implementing cutting edge technologies in partnership with companies (e.g. Leica and Zeiss).