Timeline

Fabrice Lemaitre

Research Engineer

01 Apr 2024

publication

Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.

25 Mar 2024

news

New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

05 Jun 2023

news

New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

29 May 2023

publication

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.

17 Feb 2023

publication

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.

23 Aug 2022

publication

SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.

19 Jul 2022

publication

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.

14 Jun 2021

publication

Quorum sensing governs collective dendritic cell activation in vivo.

15 Apr 2021

publication

Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.

02 Apr 2021

news

Cancer: CAR T cell function scrutinized to improve immunotherapy

26 Mar 2021

publication

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.

19 Feb 2021

news

Improving immunotherapies for blood cancers: real-time exploration in the tumor

01 Feb 2021

publication

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.

09 Mar 2020

publication

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

01 Mar 2020

publication

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.

19 Sep 2018

publication

A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses

27 Mar 2018

publication

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

21 Dec 2015

publication

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

14 Sep 2015

publication

Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest

08 Sep 2015

software

Dynamic In Situ Cytometry

15 Jun 2015

project

Lymphocyte activation in lymphoid organs

11 May 2015

team

Dynamics of Immune Responses

05 Aug 2013

publication

Origin, trafficking, and intraepithelial fate of gut-tropic T cells

08 Jul 2013

publication

Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division

03 Jan 2013

publication

GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice

26 Nov 2012

publication

Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions

15 Nov 2012

publication

Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis

26 Oct 2012

publication

Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory

12 Oct 2012

publication

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

25 Jul 2012

publication

HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term

07 Jun 2012

publication

Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo

01 Jun 2012

publication

Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer

08 Dec 2011

publication

Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery

15 Nov 2010

publication

Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state

14 Oct 2010

publication

Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression

24 Sep 2010

publication

Visualizing the functional diversification of CD8+ T cell responses in lymph nodes

26 Feb 2010

publication

HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity

04 Feb 2010

publication

Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes

01 Sep 2008

publication

Antigen persistence is required for dendritic cell licensing and CD8+ T cell cross-priming

01 Apr 2008

publication

Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice

27 Feb 2008

publication

Absence of amplification of CD4+CD25(high) regulatory T cells during in vitro expansion of tumor-infiltrating lymphocytes in melanoma patients

18 Oct 2007

publication

Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation

21 Feb 2007

publication

Severe FOXP3+ and naïve T lymphopenia in a non-IPEX form of autoimmune enteropathy combined with an immunodeficiency

01 Aug 2005

publication

Numbers of Foxp3-expressing CD4+CD25high T cells do not correlate with the establishment of long-term tolerance after allogeneic stem cell transplantation

01 Jan 2005

publication

Valpha and Vbeta public repertoires are highly conserved in terminal deoxynucleotidyl transferase-deficient mice

01 Oct 2004

publication

Detection of low-frequency human antigen-specific CD4(+) T cells using MHC class II multimer bead sorting and immunoscope analysis

15 Jul 2004

publication

Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells

01 Feb 2004

publication

Phage-displayed libraries of peptide/major histocompatibility complexes

01 Oct 2003

publication

The intratumoral application of poly-G-oligodeoxynucleotides does not augment the naturally induced antitumoral CD8-T-cell response in P815 mastocytomas

01 May 2003

publication

T cell adhesion lowers the threshold for antigen detection

01 Aug 2001

publication

Improving Escherichia coli alkaline phosphatase efficacy by additional mutations inside and outside the catalytic pocket

15 Jul 2000

publication

Facing two T cell epitopes: a degree of randomness in the primary response is lost upon secondary immunization

01 May 2000

publication

Delayed and separate costimulation in vitro supports the evidence of a transient “excited” state of CD8+ T cells during activation

01 Apr 2000

publication

The peripheral CD8 T cell repertoire is largely independent of the presence of intestinal flora

01 Oct 1998

publication

A little guide for advanced search:

Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.

New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.

SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.

Quorum sensing governs collective dendritic cell activation in vivo.

Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.

Cancer: CAR T cell function scrutinized to improve immunotherapy

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.

Improving immunotherapies for blood cancers: real-time exploration in the tumor

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.

A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest

Dynamic In Situ Cytometry

Lymphocyte activation in lymphoid organs

Dynamics of Immune Responses

Origin, trafficking, and intraepithelial fate of gut-tropic T cells

Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division

GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice

Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions

Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis

Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term

Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo

Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer

Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery

Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state

Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression

Visualizing the functional diversification of CD8+ T cell responses in lymph nodes

HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity

Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes

Antigen persistence is required for dendritic cell licensing and CD8+ T cell cross-priming

Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice

Absence of amplification of CD4+CD25(high) regulatory T cells during in vitro expansion of tumor-infiltrating lymphocytes in melanoma patients

Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation

Severe FOXP3+ and naïve T lymphopenia in a non-IPEX form of autoimmune enteropathy combined with an immunodeficiency

Numbers of Foxp3-expressing CD4+CD25high T cells do not correlate with the establishment of long-term tolerance after allogeneic stem cell transplantation

Valpha and Vbeta public repertoires are highly conserved in terminal deoxynucleotidyl transferase-deficient mice

Detection of low-frequency human antigen-specific CD4(+) T cells using MHC class II multimer bead sorting and immunoscope analysis

Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells

Phage-displayed libraries of peptide/major histocompatibility complexes

The intratumoral application of poly-G-oligodeoxynucleotides does not augment the naturally induced antitumoral CD8-T-cell response in P815 mastocytomas

T cell adhesion lowers the threshold for antigen detection

Improving Escherichia coli alkaline phosphatase efficacy by additional mutations inside and outside the catalytic pocket

Facing two T cell epitopes: a degree of randomness in the primary response is lost upon secondary immunization

Delayed and separate costimulation in vitro supports the evidence of a transient “excited” state of CD8+ T cells during activation

The peripheral CD8 T cell repertoire is largely independent of the presence of intestinal flora

CD8 expression allows T cell signaling by monomeric peptide-MHC complexes