Ligne de temps
Fabrice Lemaitre
Ingénieur(e) de Recherche
01 avr. 2024
publication
Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.
Lire plus25 mars 2024
news
New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes
Lire plus05 juin 2023
news
New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity
Lire plus29 mai 2023
publication
Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.
Lire plus17 févr. 2023
publication
Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.
Lire plus23 août 2022
publication
SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.
Lire plus19 juil. 2022
publication
Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.
Lire plus14 juin 2021
15 avr. 2021
publication
Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.
Lire plus02 avr. 2021
26 mars 2021
publication
A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.
Lire plus19 févr. 2021
01 févr. 2021
publication
Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.
Lire plus09 mars 2020
publication
Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment
Lire plus01 mars 2020
publication
Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.
Lire plus19 sept. 2018
publication
A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses
Lire plus27 mars 2018
publication
Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division
Lire plus21 déc. 2015
publication
In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity
Lire plus14 sept. 2015
publication
Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest
Lire plus08 sept. 2015
15 juin 2015
11 mai 2015
05 août 2013
08 juil. 2013
publication
Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division
Lire plus03 janv. 2013
publication
GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice
Lire plus26 nov. 2012
publication
Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions
Lire plus15 nov. 2012
publication
Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis
Lire plus26 oct. 2012
publication
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory
Lire plus12 oct. 2012
publication
Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles
Lire plus25 juil. 2012
publication
HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term
Lire plus07 juin 2012
publication
Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo
Lire plus01 juin 2012
publication
Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer
Lire plus08 déc. 2011
publication
Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery
Lire plus15 nov. 2010
publication
Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state
Lire plus14 oct. 2010
publication
Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression
Lire plus24 sept. 2010
publication
Visualizing the functional diversification of CD8+ T cell responses in lymph nodes
Lire plus26 févr. 2010
publication
HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity
Lire plus04 févr. 2010
publication
Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes
Lire plus01 sept. 2008
publication
Antigen persistence is required for dendritic cell licensing and CD8+ T cell cross-priming
Lire plus01 avr. 2008
publication
Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice
Lire plus27 févr. 2008
publication
Absence of amplification of CD4+CD25(high) regulatory T cells during in vitro expansion of tumor-infiltrating lymphocytes in melanoma patients
Lire plus18 oct. 2007
publication
Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation
Lire plus21 févr. 2007
publication
Severe FOXP3+ and naïve T lymphopenia in a non-IPEX form of autoimmune enteropathy combined with an immunodeficiency
Lire plus01 août 2005
publication
Numbers of Foxp3-expressing CD4+CD25high T cells do not correlate with the establishment of long-term tolerance after allogeneic stem cell transplantation
Lire plus01 janv. 2005
publication
Valpha and Vbeta public repertoires are highly conserved in terminal deoxynucleotidyl transferase-deficient mice
Lire plus01 oct. 2004
publication
Detection of low-frequency human antigen-specific CD4(+) T cells using MHC class II multimer bead sorting and immunoscope analysis
Lire plus15 juil. 2004
publication
Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells
Lire plus01 févr. 2004
01 oct. 2003
publication
The intratumoral application of poly-G-oligodeoxynucleotides does not augment the naturally induced antitumoral CD8-T-cell response in P815 mastocytomas
Lire plus01 mai 2003
01 août 2001
publication
Improving Escherichia coli alkaline phosphatase efficacy by additional mutations inside and outside the catalytic pocket
Lire plus15 juil. 2000
publication
Facing two T cell epitopes: a degree of randomness in the primary response is lost upon secondary immunization
Lire plus01 mai 2000
publication
Delayed and separate costimulation in vitro supports the evidence of a transient “excited” state of CD8+ T cells during activation
Lire plus01 avr. 2000
publication
The peripheral CD8 T cell repertoire is largely independent of the presence of intestinal flora
Lire plus01 oct. 1998