Timeline

Fabrice Lemaitre
Research Engineer
23 Aug 2022
publication

SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.

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19 Jul 2022
publication

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.

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14 Jun 2021
publication

Quorum sensing governs collective dendritic cell activation in vivo.

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15 Apr 2021
publication

Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.

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02 Apr 2021
news

Cancer: CAR T cell function scrutinized to improve immunotherapy

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26 Mar 2021
publication

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.

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19 Feb 2021
news

Improving immunotherapies for blood cancers: real-time exploration in the tumor

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01 Feb 2021
publication

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.

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09 Mar 2020
publication

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

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01 Mar 2020
publication

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.

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19 Sep 2018
publication

A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses

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27 Mar 2018
publication

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

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21 Dec 2015
publication

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

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14 Sep 2015
publication

Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest

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08 Sep 2015
software

Dynamic In Situ Cytometry

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15 Jun 2015
project

Lymphocyte activation in lymphoid organs

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11 May 2015
team

Dynamics of Immune Responses

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05 Aug 2013
publication

Origin, trafficking, and intraepithelial fate of gut-tropic T cells

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08 Jul 2013
publication

Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division

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03 Jan 2013
publication

GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice

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26 Nov 2012
publication

Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions

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15 Nov 2012
publication

Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis

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26 Oct 2012
publication

Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory

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12 Oct 2012
publication

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

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25 Jul 2012
publication

HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term

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07 Jun 2012
publication

Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo

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01 Jun 2012
publication

Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer

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08 Dec 2011
publication

Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery

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15 Nov 2010
publication

Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state

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14 Oct 2010
publication

Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression

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24 Sep 2010
publication

Visualizing the functional diversification of CD8+ T cell responses in lymph nodes

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26 Feb 2010
publication

HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity

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04 Feb 2010
publication

Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes

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01 Sep 2008
publication

Antigen persistence is required for dendritic cell licensing and CD8+ T cell cross-priming

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01 Apr 2008
publication

Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice

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27 Feb 2008
publication

Absence of amplification of CD4+CD25(high) regulatory T cells during in vitro expansion of tumor-infiltrating lymphocytes in melanoma patients

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18 Oct 2007
publication

Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation

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21 Feb 2007
publication

Severe FOXP3+ and naïve T lymphopenia in a non-IPEX form of autoimmune enteropathy combined with an immunodeficiency

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01 Aug 2005
publication

Numbers of Foxp3-expressing CD4+CD25high T cells do not correlate with the establishment of long-term tolerance after allogeneic stem cell transplantation

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01 Jan 2005
publication

Valpha and Vbeta public repertoires are highly conserved in terminal deoxynucleotidyl transferase-deficient mice

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01 Oct 2004
publication

Detection of low-frequency human antigen-specific CD4(+) T cells using MHC class II multimer bead sorting and immunoscope analysis

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15 Jul 2004
publication

Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells

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01 Feb 2004
publication

Phage-displayed libraries of peptide/major histocompatibility complexes

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01 Oct 2003
publication

The intratumoral application of poly-G-oligodeoxynucleotides does not augment the naturally induced antitumoral CD8-T-cell response in P815 mastocytomas

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01 May 2003
publication

T cell adhesion lowers the threshold for antigen detection

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01 Aug 2001
publication

Improving Escherichia coli alkaline phosphatase efficacy by additional mutations inside and outside the catalytic pocket

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15 Jul 2000
publication

Facing two T cell epitopes: a degree of randomness in the primary response is lost upon secondary immunization

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01 May 2000
publication

Delayed and separate costimulation in vitro supports the evidence of a transient “excited” state of CD8+ T cells during activation

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01 Apr 2000
publication

The peripheral CD8 T cell repertoire is largely independent of the presence of intestinal flora

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01 Oct 1998
publication

CD8 expression allows T cell signaling by monomeric peptide-MHC complexes

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