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© Research
Publication : Immunity

CD8 expression allows T cell signaling by monomeric peptide-MHC complexes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunity - 01 Oct 1998

Delon J, Grégoire C, Malissen B, Darche S, Lemaître F, Kourilsky P, Abastado JP, Trautmann A

Link to Pubmed [PMID] – 9806633

Immunity 1998 Oct;9(4):467-73

Physiologically, TCR signaling is unlikely to result from the cross-linking of TCR-CD3 complexes, given the low density of specific peptide-MHC complexes on antigen-presenting cells. We therefore have tested directly an alternative model for antigen recognition. We show that monomers of soluble peptide-MHC trigger Ca2+ responses in CD8alphabeta+ T cells. This response is not observed in CD8- T cells and when either the CD8:MHC or CD8:Lck interactions are prevented. This demonstrates that an intact CD8 coreceptor is necessary for effective TCR signaling in response to monomeric peptide-MHC molecules. We propose that this heterodimerization of TCR and CD8 by peptide-MHC corresponds to the physiological event normally involved during antigen-specific signal transduction.

http://www.ncbi.nlm.nih.gov/pubmed/9806633