Timeline
Artur Scherf
Head of Structure
18 Aug 2023
publication
Cohesin contributes to transcriptional repression of stage-specific genes in the human malaria parasite.
Read more22 May 2023
publication
Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors.
Read more17 Feb 2023
publication
Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum.
Read more11 Jan 2023
news
New publication: Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum
Read more01 Jan 2023
publication
Discovery of RUF6 ncRNA-interacting proteins involved in P. falciparum immune evasion.
Read more01 Jan 2023
publication
Plasmodium-encoded murine IL-6 impairs liver stage infection and elicits long-lasting sterilizing immunity.
Read more13 Oct 2022
event
DPT Parasites and insects Vectors Seminar – Nicolas Brancucci “From basic malaria research to drug discovery”
Read more01 Sep 2022
news
Paludisme : recréer le cycle sanguin du parasite in vivo pour mieux lutter contre la maladie
Read more15 Jul 2022
publication
Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission.
Read more06 May 2022
event
PIV Department seminar – Benoît Gamin- “Towards the development of a placental malaria vaccine”
Read more14 Jan 2022
event
Video seminar PIV department- Pierre Buffet “Plasmodium-induced disease in humans (malaria). Parasites, Red cells, Clearance, Persistence, and 100 spleens”
Read more02 Nov 2021
publication
Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation
Read more28 Aug 2021
publication
Flowcytometric and ImageStream Rna-Fish Gene Expression, Quantification and Phenotypic Characterization of Blood Sporozoites and Sporozoites From Human Malaria Species.
Read more22 Jul 2021
publication
Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.
Read more27 Apr 2021
publication
Functional Characterization of the m6A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite.
Read more18 Feb 2021
project
EpiKillMal- Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites –
Read more24 Sep 2019
13 Sep 2019
event
PhD defense – Clonally variant non-coding RNA family and its role in Plasmodium falciparum antigenic variation.
Read more13 Sep 2019
event
PhD Defense – DNA methylation and hydroxymethylation in Plasmodium falciparum: a potential new target for novel drug discovery.
Read more27 Mar 2019
event
“Plasmodium falciparum asymptomatic infections: in search of the elephant in the room” – Antoine Claessens
Read more14 Feb 2019
08 Jan 2019
event
Cross-talks between the human spleen and Plasmodia: exploring cell- and organ-related phenotypes – Pierre Buffet
Read more11 Jul 2017
publication
CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for var2csa Gene Activation or Silencing in Plasmodium falciparum
Read more06 Apr 2017
event
EMBO Conference on Hijacking host signalling and epigenetic mimicry during infections
Read more24 Mar 2017
event
“Regulation of PfEMP1-VAR2CSA translation by a translation-enhancing factor (PTEF)” :
Read more30 Mar 2016
event
“Insights into the B cell and Tfh cell biology underlying the inefficient acquisition of humoral immunity to malaria”
Read more08 Feb 2016
09 Dec 2015
event
“Breadth of the humoral response and antigenic targets associated with protection following experimental Plasmodium falciparum sporozoite inoculation in humans”
Read more28 Jul 2015
08 Jul 2015
project
P. berghei, a rodent malaria model to investigate host-parasite interactions central for malaria pathogenesis
Read more08 Jul 2015
project
Identification of parasite co-factors that are critical for adhesion of P. falciparum–infected RBC
Read more08 Jul 2015
08 Jul 2015
project
Nuclear biology and the identification of novel chromatin factors linked to the control of virulence gene expression and genome variability
Read more08 Jul 2015
03 Jul 2015
30 Jun 2015
publication
Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)
Read more29 Jun 2015
11 May 2015
09 Feb 2015
24 Nov 2014
publication
Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans
Read more02 Oct 2014
12 Jul 2014
publication
Noncoding RNAs as emerging regulators of Plasmodium falciparum virulence gene expression
Read more29 Jun 2014
publication
Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria
Read more01 Jun 2014
publication
Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
Read more22 Feb 2014
publication
Strand-specific RNA-Seq reveals widespread and developmentally regulated transcription of natural antisense transcripts in Plasmodium falciparum
Read more09 Feb 2014
publication
Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures
Read more03 Jul 2013
publication
PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum
Read more08 Mar 2013
publication
Nuclear pores and perinuclear expression sites of var and ribosomal DNA genes correspond to physically distinct regions in Plasmodium falciparum
Read more21 Feb 2013
publication
Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum
Read more07 Jan 2013
publication
Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites
Read more01 Jan 2013
publication
Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.
Read more01 Jan 2013
publication
In situ fluorescence visualization of transcription sites and genomic Loci in blood stages of Plasmodium falciparum.
Read more01 Jan 2013
08 Oct 2012
publication
Initial characterization of the Pf-Int recombinase from the malaria parasite Plasmodium falciparum
Read more24 Sep 2012
publication
Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum
Read more31 Jan 2012
publication
Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway
Read more19 Dec 2011
publication
Clag9 is not essential for PfEMP1 surface expression in non-cytoadherent Plasmodium falciparum parasites with a chromosome 9 deletion
Read more13 Dec 2011
publication
PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites
Read more17 Nov 2011
publication
A critical role of perinuclear filamentous actin in spatial repositioning and mutually exclusive expression of virulence genes in malaria parasites
Read more03 Sep 2010
publication
Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions
Read more23 Jul 2010
publication
Plasmodium falciparum FIKK kinase members target distinct components of the erythrocyte membrane
Read more01 Mar 2009
publication
Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum.
Read more19 Feb 2009
publication
Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites.
Read more04 Sep 2008
publication
Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
Read more11 Jul 2008
18 Jun 2008
publication
Investigation of host factors possibly enhancing the emergence of the chondroitin sulfate A-binding phenotype in Plasmodium falciparum
Read more15 Jun 2008
publication
Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum.
Read more10 Jun 2008
publication
Identification of a novel post-translational modification in Plasmodium falciparum: protein sumoylation in different cellular compartments
Read more01 Jan 2008
20 Dec 2007
publication
A novel protein kinase family in Plasmodium falciparum is differentially transcribed and secreted to various cellular compartments of the host cell
Read more19 Nov 2007
publication
5′ flanking region of var genes nucleate histone modification patterns linked to phenotypic inheritance of virulence traits in malaria parasites
Read more19 Nov 2007
19 Sep 2007
publication
Disruption of var2csa gene impairs placental malaria associated adhesion phenotype
Read more22 Dec 2006
publication
Pregnancy-associated malaria: parasite binding, natural immunity and vaccine development
Read more17 Oct 2006
publication
Characterization of anti-var2CSA-PfEMP1 cytoadhesion inhibitory mouse monoclonal antibodies
Read more27 Jan 2006
07 Nov 2005
publication
The human placental derived BeWo cell line: a useful model for selecting Plasmodium falciparum CSA-binding parasites
Read more31 Oct 2005
publication
Transcriptome analysis of antigenic variation in Plasmodium falciparum–var silencing is not dependent on antisense RNA
Read more01 Sep 2005
01 Aug 2005
publication
A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A
Read more01 Aug 2005
08 Apr 2005
publication
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites.
Read more29 Mar 2005
publication
Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations
Read more11 Feb 2005
publication
Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites
Read more01 Jan 2005
publication
The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus.
Read more15 Feb 2002
publication