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© Research
Event

“Regulation of PfEMP1-VAR2CSA translation by a translation-enhancing factor (PTEF)” :

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
27
Apr 2017
Time
12:00:00
28 Rue du Docteur Roux, Paris, France
Address
Building: Lwolf Room: Retrovirus
Location
2017-04-27 12:00:00 2017-04-27 14:00:00 Europe/Paris “Regulation of PfEMP1-VAR2CSA translation by a translation-enhancing factor (PTEF)” : Mats WAHLGREN – Karolinska Institutet (Stockholm – Suède) Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum infected erythrocytes to placental chondroitin sulfate A through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed by an […] 28 Rue du Docteur Roux, Paris, France Artur Scherf artur.scherf@pasteur.fr

About

Mats WAHLGRENKarolinska Institutet (Stockholm – Suède)

Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum infected erythrocytes to placental chondroitin sulfate A through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed by an upstream open reading frame. I will discuss a novel Plasmodium falciparum translation enhancing factor that relieves uORF repression and thereby facilitates VAR2CSA translation. It also enhances translation in a heterologous translation system and thus represents the first non-canonical translation enhancing factor to be found in a protozoan. Our results implicate PTEF in regulating placental CSA binding of IE.

Contact : Artur SCHERF (artur.scherf@pasteur.fr – Poste : 86 16)

Location

Building: Lwolf
Room: Retrovirus
Address: 28 Rue du Docteur Roux, Paris, France