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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Cell

A greedy promoter controls malarial var-iations

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell - 27 Jan 2006

Scherf A

Link to Pubmed [PMID] – 16439197

Cell 2006 Jan;124(2):251-3

Immune evasion by the malaria parasite Plasmodium falciparum is mediated by the mutually exclusive expression of a single member of the var family of genes, which encode variant surface antigens. In a recent paper in Nature, demonstrate that a construct carrying a transcriptionally active var promoter is sufficient to promote allelic exclusion of the parasite’s endogenous var gene.

http://www.ncbi.nlm.nih.gov/pubmed/16439197