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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Current opinion in microbiology

The epigenetic control of antigenic variation in Plasmodium falciparum

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 01 Aug 2005

Ralph SA, Scherf A

Link to Pubmed [PMID] – 15979386

Curr. Opin. Microbiol. 2005 Aug;8(4):434-40

Much of what is known about antigenic variation in the human malaria parasite Plasmodium falciparum has been established by the study of phenotypic changes at the surface of parasitized red blood cells. Although this has contributed to our fundamental understanding of immune escape, nothing conclusive has been elucidated about the molecular mechanisms that determine activation and silencing of members of the antigenic variation var gene family. Recent findings indicate that reversible chromatin modifications and perinuclear gene movement are epigenetic factors that define the silent and active states of telomere-adjacent var genes.

http://www.ncbi.nlm.nih.gov/pubmed/15979386