Ligne de temps

Artur Scherf
Responsable de Structure
27 Mar 2019
event

“Plasmodium falciparum asymptomatic infections: in search of the elephant in the room” – Antoine Claessens

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14 Feb 2019
team

Bases génétiques et moléculaires des interactions hôte-parasite

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08 Jan 2019
event

Cross-talks between the human spleen and Plasmodia: exploring cell- and organ-related phenotypes – Pierre Buffet

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11 Jul 2017
publication

CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for var2csa Gene Activation or Silencing in Plasmodium falciparum

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06 Apr 2017
event

EMBO Conference on Hijacking host signalling and epigenetic mimicry during infections

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24 Mar 2017
event

“Regulation of PfEMP1-VAR2CSA translation by a translation-enhancing factor (PTEF)” :

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30 Mar 2016
event

“Insights into the B cell and Tfh cell biology underlying the inefficient acquisition of humoral immunity to malaria”

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08 Feb 2016
event

“P.falciparum resistance to artemisinins: who cares?”

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09 Dec 2015
event

“Breadth of the humoral response and antigenic targets associated with protection following experimental Plasmodium falciparum sporozoite inoculation in humans”

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05 Sep 2015
project

Plasmodium integrase Pf-Int – role in DNA transactions

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28 Jul 2015
project

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

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08 Jul 2015
project

P. berghei, a rodent malaria model to investigate host-parasite interactions central for malaria pathogenesis

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08 Jul 2015
project

Identification of parasite co-factors that are critical for adhesion of P. falciparum–infected RBC

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08 Jul 2015
project

Targeting epigenetic factors for new intervention strategies

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08 Jul 2015
project

Nuclear biology and the identification of novel chromatin factors linked to the control of virulence gene expression and genome variability

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08 Jul 2015
project

Molecular mechanism of antigenic variation of P. falciparum

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03 Jul 2015
project

From basic research to new intervention strategies against malaria parasites

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30 Jun 2015
publication

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

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29 Jun 2015
publication

Flexible guide-RNA design for CRISPR applications using Protospacer Workbench

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11 May 2015
team

Biologie des interactions hôte-parasite

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09 Feb 2015
publication

Post-translational protein modifications in malaria parasites

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24 Nov 2014
publication

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans

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02 Oct 2014
publication

P. berghei telomerase subunit TERT is essential for parasite survival

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12 Jul 2014
publication

Noncoding RNAs as emerging regulators of Plasmodium falciparum virulence gene expression

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29 Jun 2014
publication

Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

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01 Jun 2014
publication

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

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22 Feb 2014
publication

Strand-specific RNA-Seq reveals widespread and developmentally regulated transcription of natural antisense transcripts in Plasmodium falciparum

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09 Feb 2014
publication

Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

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03 Jul 2013
publication

PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum

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08 Mar 2013
publication

Nuclear pores and perinuclear expression sites of var and ribosomal DNA genes correspond to physically distinct regions in Plasmodium falciparum

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21 Feb 2013
publication

Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum

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07 Jan 2013
publication

Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites

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01 Jan 2013
publication

Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum

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01 Jan 2013
publication

In situ fluorescence visualization of transcription sites and genomic Loci in blood stages of Plasmodium falciparum

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01 Jan 2013
publication

Genome-wide chromatin immunoprecipitation-sequencing in Plasmodium

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08 Oct 2012
publication

Initial characterization of the Pf-Int recombinase from the malaria parasite Plasmodium falciparum

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24 Sep 2012
publication

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

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31 Jan 2012
publication

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway

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19 Dec 2011
publication

Clag9 is not essential for PfEMP1 surface expression in non-cytoadherent Plasmodium falciparum parasites with a chromosome 9 deletion

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13 Dec 2011
publication

PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites

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17 Nov 2011
publication

A critical role of perinuclear filamentous actin in spatial repositioning and mutually exclusive expression of virulence genes in malaria parasites

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03 Sep 2010
publication

Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions

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09 Aug 2010
publication

Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites

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23 Jul 2010
publication

Plasmodium falciparum FIKK kinase members target distinct components of the erythrocyte membrane

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01 Mar 2010
publication

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

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19 Feb 2009
publication

Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites

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27 Dec 2008
publication

Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum

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04 Sep 2008
publication

Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites

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11 Jul 2008
publication

SnapShot: var gene expression in the malaria parasite

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18 Jun 2008
publication

Investigation of host factors possibly enhancing the emergence of the chondroitin sulfate A-binding phenotype in Plasmodium falciparum

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15 Jun 2008
publication

Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum

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10 Jun 2008
publication

Identification of a novel post-translational modification in Plasmodium falciparum: protein sumoylation in different cellular compartments

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01 Jan 2008
publication

Antigenic variation in Plasmodium falciparum

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20 Dec 2007
publication

A novel protein kinase family in Plasmodium falciparum is differentially transcribed and secreted to various cellular compartments of the host cell

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19 Nov 2007
publication

5′ flanking region of var genes nucleate histone modification patterns linked to phenotypic inheritance of virulence traits in malaria parasites

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19 Nov 2007
publication

Shared epigenetic mechanisms control virulence factors in protozoan parasites

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19 Sep 2007
publication

Disruption of var2csa gene impairs placental malaria associated adhesion phenotype

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22 Dec 2006
publication

Pregnancy-associated malaria: parasite binding, natural immunity and vaccine development

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17 Oct 2006
publication

Characterization of anti-var2CSA-PfEMP1 cytoadhesion inhibitory mouse monoclonal antibodies

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27 Jan 2006
publication

A greedy promoter controls malarial var-iations

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07 Nov 2005
publication

The human placental derived BeWo cell line: a useful model for selecting Plasmodium falciparum CSA-binding parasites

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31 Oct 2005
publication

Transcriptome analysis of antigenic variation in Plasmodium falciparum–var silencing is not dependent on antisense RNA

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01 Sep 2005
publication

BioMalPar–a collaborative network of excellence on basic malaria research

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01 Aug 2005
publication

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A

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01 Aug 2005
publication

The epigenetic control of antigenic variation in Plasmodium falciparum

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08 Apr 2005
publication

Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites

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29 Mar 2005
publication

Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations

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18 Feb 2005
publication

The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus

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11 Feb 2005
publication

Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites

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15 Feb 2002
publication

A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation

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