Ligne de temps
Artur Scherf
Responsable de Structure
01 juil. 2025
publication
High-resolution map of the Plasmodium falciparum genome reveals MORC/ ApiAP2-mediated links between distant, functionally related genes
Lire plus26 juin 2024
18 août 2023
publication
Cohesin contributes to transcriptional repression of stage-specific genes in the human malaria parasite.
Lire plus22 mai 2023
publication
Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors.
Lire plus17 févr. 2023
publication
Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum.
Lire plus11 janv. 2023
news
New publication: Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum
Lire plus01 janv. 2023
publication
Discovery of RUF6 ncRNA-interacting proteins involved in P. falciparum immune evasion.
Lire plus01 janv. 2023
publication
Plasmodium-encoded murine IL-6 impairs liver stage infection and elicits long-lasting sterilizing immunity.
Lire plus13 oct. 2022
event
DPT Parasites and insects Vectors Seminar – Nicolas Brancucci “From basic malaria research to drug discovery”
Lire plus01 sept. 2022
news
Paludisme : recréer le cycle sanguin du parasite in vivo pour mieux lutter contre la maladie
Lire plus15 juil. 2022
publication
Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission.
Lire plus06 mai 2022
event
PIV Department seminar – Benoît Gamin- “Towards the development of a placental malaria vaccine”
Lire plus14 janv. 2022
event
Video seminar PIV department- Pierre Buffet “Plasmodium-induced disease in humans (malaria). Parasites, Red cells, Clearance, Persistence, and 100 spleens”
Lire plus02 nov. 2021
publication
Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation
Lire plus28 août 2021
publication
Flowcytometric and ImageStream Rna-Fish Gene Expression, Quantification and Phenotypic Characterization of Blood Sporozoites and Sporozoites From Human Malaria Species.
Lire plus22 juil. 2021
publication
Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.
Lire plus27 avr. 2021
publication
Functional Characterization of the m6A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite.
Lire plus18 févr. 2021
project
EpiKillMal- Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites –
Lire plus24 sept. 2019
13 sept. 2019
event
PhD defense – Clonally variant non-coding RNA family and its role in Plasmodium falciparum antigenic variation.
Lire plus13 sept. 2019
event
PhD Defense – DNA methylation and hydroxymethylation in Plasmodium falciparum: a potential new target for novel drug discovery.
Lire plus27 mars 2019
event
“Plasmodium falciparum asymptomatic infections: in search of the elephant in the room” – Antoine Claessens
Lire plus08 janv. 2019
event
Cross-talks between the human spleen and Plasmodia: exploring cell- and organ-related phenotypes – Pierre Buffet
Lire plus06 avr. 2017
event
EMBO Conference on Hijacking host signalling and epigenetic mimicry during infections
Lire plus24 mars 2017
event
“Regulation of PfEMP1-VAR2CSA translation by a translation-enhancing factor (PTEF)” :
Lire plus30 mars 2016
event
“Insights into the B cell and Tfh cell biology underlying the inefficient acquisition of humoral immunity to malaria”
Lire plus08 févr. 2016
09 déc. 2015
event
“Breadth of the humoral response and antigenic targets associated with protection following experimental Plasmodium falciparum sporozoite inoculation in humans”
Lire plus28 juil. 2015
08 juil. 2015
project
P. berghei, a rodent malaria model to investigate host-parasite interactions central for malaria pathogenesis
Lire plus08 juil. 2015
project
Identification of parasite co-factors that are critical for adhesion of P. falciparum–infected RBC
Lire plus08 juil. 2015
08 juil. 2015
project
Nuclear biology and the identification of novel chromatin factors linked to the control of virulence gene expression and genome variability
Lire plus08 juil. 2015
03 juil. 2015
30 juin 2015
publication
Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)
Lire plus29 juin 2015
11 mai 2015
09 févr. 2015
24 nov. 2014
publication
Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans
Lire plus02 oct. 2014
12 juil. 2014
publication
Noncoding RNAs as emerging regulators of Plasmodium falciparum virulence gene expression
Lire plus29 juin 2014
publication
Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria
Lire plus01 juin 2014
publication
Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
Lire plus22 févr. 2014
publication
Strand-specific RNA-Seq reveals widespread and developmentally regulated transcription of natural antisense transcripts in Plasmodium falciparum
Lire plus09 févr. 2014
publication
Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures
Lire plus03 juil. 2013
publication
PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum
Lire plus08 mars 2013
publication
Nuclear pores and perinuclear expression sites of var and ribosomal DNA genes correspond to physically distinct regions in Plasmodium falciparum
Lire plus21 févr. 2013
publication
Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum
Lire plus07 janv. 2013
publication
Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites
Lire plus01 janv. 2013
publication
Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.
Lire plus01 janv. 2013
publication
In situ fluorescence visualization of transcription sites and genomic Loci in blood stages of Plasmodium falciparum.
Lire plus01 janv. 2013
08 oct. 2012
publication
Initial characterization of the Pf-Int recombinase from the malaria parasite Plasmodium falciparum
Lire plus24 sept. 2012
publication
Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum
Lire plus31 janv. 2012
publication
Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway
Lire plus19 déc. 2011
publication
Clag9 is not essential for PfEMP1 surface expression in non-cytoadherent Plasmodium falciparum parasites with a chromosome 9 deletion
Lire plus13 déc. 2011
publication
PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites
Lire plus17 nov. 2011
publication
A critical role of perinuclear filamentous actin in spatial repositioning and mutually exclusive expression of virulence genes in malaria parasites
Lire plus03 sept. 2010
publication
Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions
Lire plus23 juil. 2010
publication
Plasmodium falciparum FIKK kinase members target distinct components of the erythrocyte membrane
Lire plus01 mars 2009
publication
Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum.
Lire plus19 févr. 2009
publication
Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites.
Lire plus04 sept. 2008
publication
Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
Lire plus11 juil. 2008
18 juin 2008
publication
Investigation of host factors possibly enhancing the emergence of the chondroitin sulfate A-binding phenotype in Plasmodium falciparum
Lire plus15 juin 2008
publication
Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum.
Lire plus10 juin 2008
publication
Identification of a novel post-translational modification in Plasmodium falciparum: protein sumoylation in different cellular compartments
Lire plus01 janv. 2008
20 déc. 2007
publication
A novel protein kinase family in Plasmodium falciparum is differentially transcribed and secreted to various cellular compartments of the host cell
Lire plus19 nov. 2007
publication
5′ flanking region of var genes nucleate histone modification patterns linked to phenotypic inheritance of virulence traits in malaria parasites
Lire plus19 nov. 2007
19 sept. 2007
publication
Disruption of var2csa gene impairs placental malaria associated adhesion phenotype
Lire plus22 déc. 2006
publication
Pregnancy-associated malaria: parasite binding, natural immunity and vaccine development
Lire plus17 oct. 2006
publication
Characterization of anti-var2CSA-PfEMP1 cytoadhesion inhibitory mouse monoclonal antibodies
Lire plus27 janv. 2006
07 nov. 2005
publication
The human placental derived BeWo cell line: a useful model for selecting Plasmodium falciparum CSA-binding parasites
Lire plus31 oct. 2005
publication
Transcriptome analysis of antigenic variation in Plasmodium falciparum–var silencing is not dependent on antisense RNA
Lire plus01 sept. 2005
01 août 2005
01 août 2005
publication
A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A
Lire plus08 avr. 2005
publication
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites.
Lire plus29 mars 2005
publication
Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations
Lire plus11 févr. 2005
publication
Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites
Lire plus01 janv. 2005
publication
The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus.
Lire plus15 févr. 2002
publication