Timeline

Sandra Pellegrini

Head of Structure

20 Oct 2023

publication

Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.

01 Jan 2022

publication

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation.

04 Jan 2021

publication

Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency.

01 Jan 2021

publication

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.

01 Aug 2020

publication

An Old Cytokine Against a New Virus?

28 Apr 2020

publication

COPZ1 depletion in thyroid tumor cells triggers type I IFN response and immunogenic cell death.

01 Jan 2020

publication

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3’Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21.

01 Jan 2020

publication

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage.

11 Mar 2019

publication

USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression

21 Dec 2018

publication

Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant

26 Oct 2018

publication

Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds

15 Mar 2017

event

Karl-Sebastian LANG seminar

27 Feb 2017

publication

Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors

06 Feb 2017

publication

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

12 Dec 2016

publication

Mycolactone subverts immunity by selectively blocking the Sec61 translocon.

20 Jun 2016

publication

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

19 May 2016

publication

ISG15 deficiency and increased viral resistance in humans but not mice

29 Apr 2016

publication

The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells

15 Sep 2015

project

TYK2 variants in cytokine signaling and autoimmune diseases

15 Sep 2015

project

Exploring a link between ISGylation and cell cycle via SKP2

15 Sep 2015

project

Fine-tuning of IFN-I response by USP18

24 Jul 2015

publication

Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes

25 May 2015

publication

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

14 May 2015

publication

IFNA2: The prototypic human alpha interferon

12 Oct 2014

publication

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

15 Jul 2013

publication

Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⁺ T cells

01 Dec 2012

publication

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity

15 Sep 2012

publication

USP18 establishes the transcriptional and anti-proliferative interferon α/β differential

03 Jan 2012

publication

Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor

01 Dec 2011

publication

Pillars article: A protein tyrosine kinase in the interferon α/β signaling pathway. Cell. 1992. 70: 313-322

14 Jul 2011

publication

USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response

01 Jun 2011

publication

Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family

30 Nov 2010

publication

T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells

13 Aug 2010

publication

Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes

01 Feb 2010

publication

Biochemical monitoring of the early endocytic traffic of the type I interferon receptor

17 Jul 2009

publication

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

29 Jun 2009

publication

Receptor density is key to the alpha2/beta interferon differential activities

01 Nov 2008

publication

Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes

12 May 2008

publication

Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif

02 May 2008

publication

The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor

31 Dec 2007

publication

Ligand-independent pathway that controls stability of interferon alpha receptor

01 Oct 2007

publication

Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2

21 May 2007

publication

Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways

17 Oct 2006

publication

NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation

03 Oct 2006

publication

Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation

01 Jul 2006

publication

TYK2 activity promotes ligand-induced IFNAR1 proteolysis

19 Apr 2006

publication

Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression

15 Sep 2004

publication

A dual role of IFN-alpha in the balance between proliferation and death of human CD4+ T lymphocytes during primary response

23 Jul 2004

publication

Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules

18 Sep 2003

publication

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

01 Feb 2003

publication

The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression

15 Jan 2003

publication

Down-modulation of responses to type I IFN upon T cell activation

01 Jul 2002

publication

A little guide for advanced search:

Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation.

Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency.

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.

An Old Cytokine Against a New Virus?

COPZ1 depletion in thyroid tumor cells triggers type I IFN response and immunogenic cell death.

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3’Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21.

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage.

USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression

Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant

Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds

Karl-Sebastian LANG seminar

Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Mycolactone subverts immunity by selectively blocking the Sec61 translocon.

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

ISG15 deficiency and increased viral resistance in humans but not mice

The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells

TYK2 variants in cytokine signaling and autoimmune diseases

Exploring a link between ISGylation and cell cycle via SKP2

Fine-tuning of IFN-I response by USP18

Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

IFNA2: The prototypic human alpha interferon

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⁺ T cells

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity

USP18 establishes the transcriptional and anti-proliferative interferon α/β differential

Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor

Pillars article: A protein tyrosine kinase in the interferon α/β signaling pathway. Cell. 1992. 70: 313-322

USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response

Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family

T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells

Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes

Biochemical monitoring of the early endocytic traffic of the type I interferon receptor

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

Receptor density is key to the alpha2/beta interferon differential activities

Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes

Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif

The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor

Ligand-independent pathway that controls stability of interferon alpha receptor

Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2

Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways

NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation

Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation

TYK2 activity promotes ligand-induced IFNAR1 proteolysis

Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression

A dual role of IFN-alpha in the balance between proliferation and death of human CD4+ T lymphocytes during primary response

Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression

Down-modulation of responses to type I IFN upon T cell activation

Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis