Ligne de temps
Sandra Pellegrini
Responsable de Structure
20 oct. 2023
publication
Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
Lire plus01 janv. 2022
publication
IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation.
Lire plus04 janv. 2021
publication
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency.
Lire plus01 janv. 2021
publication
Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.
Lire plus01 août 2020
28 avr. 2020
publication
COPZ1 depletion in thyroid tumor cells triggers type I IFN response and immunogenic cell death.
Lire plus01 janv. 2020
publication
Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3’Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21.
Lire plus01 janv. 2020
publication
Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage.
Lire plus11 mars 2019
21 déc. 2018
publication
Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant
Lire plus26 oct. 2018
publication
Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds
Lire plus15 mars 2017
27 févr. 2017
publication
Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors
Lire plus06 févr. 2017
publication
STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling
Lire plus12 déc. 2016
20 juin 2016
publication
Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome
Lire plus19 mai 2016
29 avr. 2016
publication
The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
Lire plus15 sept. 2015
15 sept. 2015
15 sept. 2015
24 juil. 2015
publication
Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes
Lire plus25 mai 2015
publication
Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling
Lire plus14 mai 2015
12 oct. 2014
publication
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
Lire plus15 juil. 2013
publication
Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⁺ T cells
Lire plus01 déc. 2012
15 sept. 2012
publication
USP18 establishes the transcriptional and anti-proliferative interferon α/β differential
Lire plus03 janv. 2012
publication
Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor
Lire plus01 déc. 2011
publication
Pillars article: A protein tyrosine kinase in the interferon α/β signaling pathway. Cell. 1992. 70: 313-322
Lire plus14 juil. 2011
publication
USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response
Lire plus01 juin 2011
publication
Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family
Lire plus30 nov. 2010
publication
T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells
Lire plus13 août 2010
publication
Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes
Lire plus01 févr. 2010
publication
Biochemical monitoring of the early endocytic traffic of the type I interferon receptor
Lire plus17 juil. 2009
publication
Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense
Lire plus29 juin 2009
01 nov. 2008
publication
Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes
Lire plus12 mai 2008
publication
Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif
Lire plus02 mai 2008
publication
The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor
Lire plus31 déc. 2007
publication
Ligand-independent pathway that controls stability of interferon alpha receptor
Lire plus01 oct. 2007
publication
Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2
Lire plus21 mai 2007
publication
Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways
Lire plus17 oct. 2006
publication
NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation
Lire plus03 oct. 2006
publication
Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation
Lire plus01 juil. 2006
19 avr. 2006
publication
Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression
Lire plus15 sept. 2004
publication
A dual role of IFN-alpha in the balance between proliferation and death of human CD4+ T lymphocytes during primary response
Lire plus23 juil. 2004
publication
Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules
Lire plus18 sept. 2003
publication
A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity
Lire plus01 févr. 2003
15 janv. 2003
01 juil. 2002
publication