Timeline

Sandra Pellegrini
Head of Structure
11 Mar 2019
publication

USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression

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21 Dec 2018
publication

Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant

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26 Oct 2018
publication

Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds

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15 Mar 2017
event

Karl-Sebastian LANG seminar

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27 Feb 2017
publication

Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors

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06 Feb 2017
publication

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

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07 Nov 2016
publication

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

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20 Jun 2016
publication

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

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19 May 2016
publication

ISG15 deficiency and increased viral resistance in humans but not mice

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29 Apr 2016
publication

The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells

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15 Sep 2015
project

TYK2 variants in cytokine signaling and autoimmune diseases

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15 Sep 2015
project

IFN-I and translational control

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15 Sep 2015
project

Exploring a link between ISGylation and cell cycle via SKP2

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15 Sep 2015
project

ISG15 contribution to tuning of IFN-I activity and interferonopathies

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15 Sep 2015
project

Fine-tuning of IFN-I response by USP18

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24 Jul 2015
publication

Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes

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25 May 2015
publication

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

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14 May 2015
publication

IFNA2: The prototypic human alpha interferon

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11 May 2015
team

Cytokine Signaling

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12 Oct 2014
publication

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

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15 Jul 2013
publication

Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⁺ T cells

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28 Jan 2013
publication

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent

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01 Dec 2012
publication

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity

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15 Sep 2012
publication

USP18 establishes the transcriptional and anti-proliferative interferon α/β differential

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03 Jan 2012
publication

Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor

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01 Dec 2011
publication

Pillars article: A protein tyrosine kinase in the interferon α/β signaling pathway. Cell. 1992. 70: 313-322

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14 Jul 2011
publication

USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response

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01 Jun 2011
publication

Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family

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30 Nov 2010
publication

T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells

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13 Aug 2010
publication

Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes

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01 Feb 2010
publication

Biochemical monitoring of the early endocytic traffic of the type I interferon receptor

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17 Jul 2009
publication

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

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29 Jun 2009
publication

Receptor density is key to the alpha2/beta interferon differential activities

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01 Nov 2008
publication

Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes

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12 May 2008
publication

Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif

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02 May 2008
publication

The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor

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31 Dec 2007
publication

Ligand-independent pathway that controls stability of interferon alpha receptor

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01 Oct 2007
publication

Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2

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21 May 2007
publication

Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways

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17 Oct 2006
publication

NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation

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03 Oct 2006
publication

Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation

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01 Jul 2006
publication

TYK2 activity promotes ligand-induced IFNAR1 proteolysis

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19 Apr 2006
publication

Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression

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15 Sep 2004
publication

A dual role of IFN-alpha in the balance between proliferation and death of human CD4+ T lymphocytes during primary response

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23 Jul 2004
publication

Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules

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18 Sep 2003
publication

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

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01 Feb 2003
publication

The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression

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15 Jan 2003
publication

Down-modulation of responses to type I IFN upon T cell activation

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01 Jul 2002
publication

Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis

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