Timeline

Alphonse Garcia

Permanent Researcher

28 Sep 2017

team

Design for Biology

26 Oct 2015

project

PP2A1 is a target for Alzheimer disease

26 Oct 2015

project

PP2A a key target for viruses

17 Oct 2015

project

The trimeric ABαC phosphatase named PP2A1 is a target for cancer therapy

17 Sep 2015

project

PP2A a key target for viruses

14 Mar 2013

publication

Transducing properties of a pre-structured α-helical DPT-peptide containing a short canine adenovirus type 2 E4orf4 PP2A1-binding sequence

23 Dec 2011

publication

[Targeting of PP2A enzymes by viral proteins and cancer signalling]

10 Aug 2011

publication

PP2A targeting by viral proteins: a widespread biological strategy from DNA/RNA tumor viruses to HIV-1

01 Nov 2010

publication

PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins

01 Apr 2010

publication

The combinatorial PP1-binding consensus Motif (R/K)x( (0,1))V/IxFxx(R/K)x(R/K) is a new apoptotic signature

24 Feb 2010

publication

Sustained gonadotropin-releasing hormone stimulation mobilizes the cAMP/PKA pathway to induce nitric oxide synthase type 1 expression in rat pituitary cells in vitro and in vivo at proestrus

17 Jan 2007

publication

Functional interaction of Aurora-A and PP2A during mitosis

01 Aug 2006

publication

A PKA survival pathway inhibited by DPT-PKI, a new specific cell permeable PKA inhibitor, is induced by T. annulata in parasitized B-lymphocytes

30 Dec 2005

publication

Use of penetrating peptides interacting with PP1/PP2A proteins as a general approach for a drug phosphatase technology

01 Dec 2004

publication

Bad-dependent rafts alteration is a consequence of an early intracellular signal triggered by interleukin-4 deprivation

01 Feb 2004

publication

New insights in protein phosphorylation: a signature for protein phosphatase 1 interacting proteins

01 Aug 2003

publication

Apoptosis of Theileria-infected lymphocytes induced upon parasite death involves activation of caspases 9 and 3

01 Aug 2003

publication

Protein phosphatase 2A as a new target for morphogenetic studies in the chick limb

01 Aug 2003

publication

Rafts: a simple way to control apoptosis by subcellular redistribution

01 Aug 2003

publication

Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis

06 Feb 2003

publication

Actin dynamics is controlled by a casein kinase II and phosphatase 2C interplay on Toxoplasma gondii Toxofilin

01 Jul 2002

publication

The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad

01 Apr 2002

publication

Segregation of Bad from lipid rafts is implicated in the induction of apoptosis

01 Mar 2002

publication

A role for Toxoplasma gondii type 1 ser/thr protein phosphatase in host cell invasion

15 Jun 2001

publication

Bcl-2 targets protein phosphatase 1 alpha to Bad

22 Sep 2000

publication

A novel role for protein phosphatase 2A in the dopaminergic regulation of Na,K-ATPase

01 Sep 2000

publication

A Theileria parva type 1 protein phosphatase activity

31 Mar 2000

publication

Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters

01 Mar 1999

publication

A family of PP2 phosphatases in Plasmodium falciparum and parasitic protozoa

10 Sep 1998

publication

The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT

01 Nov 1997

publication

Rho prevents apoptosis through Bcl-2 expression: implications for interleukin-2 receptor signal transduction

01 Nov 1997

publication

The glucocorticoid receptor and AP-1 are involved in a positive regulation of the muscle regulatory gene myf5 in cultured myoblasts

15 Sep 1997

publication

Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation

01 Jul 1997

publication

Ras activation leads to cell proliferation or apoptotic cell death upon interleukin-2 stimulation or lymphokine deprivation, respectively

01 Jun 1997

publication

Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity

01 May 1997

publication

Wortmannin inhibits IGF-dependent differentiation in the mouse myogenic cell line C2

15 Feb 1997

publication

IL-2 signaling controls actin organization through Rho-like protein family, phosphatidylinositol 3-kinase, and protein kinase C-zeta

15 Sep 1996

publication

Critical role of Ras in the proliferation and prevention of apoptosis mediated by IL-2

01 Aug 1996

publication

Association of phosphatidylinositol 3 kinase to protein kinase C zeta during interleukin-2 stimulation

01 Mar 1996

publication

Human cytomegalovirus carries serine/threonine protein phosphatases PP1 and a host-cell derived PP2A

01 Dec 1995

publication

HIV genome transcription induced by polyoma virus middle T antigen through both enhancer- and promoter-dependent LTR activation

01 Sep 1995

publication

Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton

20 Jul 1995

publication

Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A

01 May 1995

publication

The zeta isoform of protein kinase C controls interleukin-2-mediated proliferation in a murine T cell line: evidence for an additional role of protein kinase C epsilon and beta

20 Apr 1995

publication

Induction of Sp1 phosphorylation and NF-kappa B-independent HIV promoter domain activity in T lymphocytes stimulated by okadaic acid

01 Apr 1995

publication

Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2

01 Mar 1995

publication

A role for the intermediate affinity IL-2R in the protection against glucocorticoid-induced apoptosis

01 Jul 1994

publication

Implication of protein kinase C in IL-2-mediated proliferation and apoptosis in a murine T cell clone

01 Jul 1993

publication

High-affinity and intermediate-affinity forms of the human interleukin 2 receptor, expressed in an interleukin 9-dependent murine T cell line, deliver proliferative signals via differences in their transduction pathways

01 Dec 1989

publication

Partial deduced sequence of the 110-kD-calmodulin complex of the avian intestinal microvillus shows that this mechanoenzyme is a member of the myosin I family

01 Nov 1988

publication

Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity

01 Jan 1988

publication

Villin, a specific marker for some epithelia specialized in transport, to study the differentiation of intestinal and kidney cells in vivo and in a human colon adenocarcinoma line HT29 in culture

01 Dec 1986

publication

A human villin cDNA clone to investigate the differentiation of intestinal and kidney cells in vivo and in culture

01 Aug 1980

publication

A little guide for advanced search:

Design for Biology

PP2A1 is a target for Alzheimer disease

PP2A a key target for viruses

The trimeric ABαC phosphatase named PP2A1 is a target for cancer therapy

PP2A a key target for viruses

Transducing properties of a pre-structured α-helical DPT-peptide containing a short canine adenovirus type 2 E4orf4 PP2A1-binding sequence

[Targeting of PP2A enzymes by viral proteins and cancer signalling]

PP2A targeting by viral proteins: a widespread biological strategy from DNA/RNA tumor viruses to HIV-1

PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins

The combinatorial PP1-binding consensus Motif (R/K)x( (0,1))V/IxFxx(R/K)x(R/K) is a new apoptotic signature

Sustained gonadotropin-releasing hormone stimulation mobilizes the cAMP/PKA pathway to induce nitric oxide synthase type 1 expression in rat pituitary cells in vitro and in vivo at proestrus

Functional interaction of Aurora-A and PP2A during mitosis

A PKA survival pathway inhibited by DPT-PKI, a new specific cell permeable PKA inhibitor, is induced by T. annulata in parasitized B-lymphocytes

Use of penetrating peptides interacting with PP1/PP2A proteins as a general approach for a drug phosphatase technology

Bad-dependent rafts alteration is a consequence of an early intracellular signal triggered by interleukin-4 deprivation

New insights in protein phosphorylation: a signature for protein phosphatase 1 interacting proteins

Apoptosis of Theileria-infected lymphocytes induced upon parasite death involves activation of caspases 9 and 3

Protein phosphatase 2A as a new target for morphogenetic studies in the chick limb

Rafts: a simple way to control apoptosis by subcellular redistribution

Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis

Actin dynamics is controlled by a casein kinase II and phosphatase 2C interplay on Toxoplasma gondii Toxofilin

The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad

Segregation of Bad from lipid rafts is implicated in the induction of apoptosis

A role for Toxoplasma gondii type 1 ser/thr protein phosphatase in host cell invasion

Bcl-2 targets protein phosphatase 1 alpha to Bad

A novel role for protein phosphatase 2A in the dopaminergic regulation of Na,K-ATPase

A Theileria parva type 1 protein phosphatase activity

Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters

A family of PP2 phosphatases in Plasmodium falciparum and parasitic protozoa

The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT

Rho prevents apoptosis through Bcl-2 expression: implications for interleukin-2 receptor signal transduction

The glucocorticoid receptor and AP-1 are involved in a positive regulation of the muscle regulatory gene myf5 in cultured myoblasts

Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation

Ras activation leads to cell proliferation or apoptotic cell death upon interleukin-2 stimulation or lymphokine deprivation, respectively

Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity

Wortmannin inhibits IGF-dependent differentiation in the mouse myogenic cell line C2

IL-2 signaling controls actin organization through Rho-like protein family, phosphatidylinositol 3-kinase, and protein kinase C-zeta

Critical role of Ras in the proliferation and prevention of apoptosis mediated by IL-2

Association of phosphatidylinositol 3 kinase to protein kinase C zeta during interleukin-2 stimulation

Human cytomegalovirus carries serine/threonine protein phosphatases PP1 and a host-cell derived PP2A

HIV genome transcription induced by polyoma virus middle T antigen through both enhancer- and promoter-dependent LTR activation

Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton

Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A

The zeta isoform of protein kinase C controls interleukin-2-mediated proliferation in a murine T cell line: evidence for an additional role of protein kinase C epsilon and beta

Induction of Sp1 phosphorylation and NF-kappa B-independent HIV promoter domain activity in T lymphocytes stimulated by okadaic acid

Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2

A role for the intermediate affinity IL-2R in the protection against glucocorticoid-induced apoptosis

Implication of protein kinase C in IL-2-mediated proliferation and apoptosis in a murine T cell clone

High-affinity and intermediate-affinity forms of the human interleukin 2 receptor, expressed in an interleukin 9-dependent murine T cell line, deliver proliferative signals via differences in their transduction pathways

Partial deduced sequence of the 110-kD-calmodulin complex of the avian intestinal microvillus shows that this mechanoenzyme is a member of the myosin I family

Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity

Villin, a specific marker for some epithelia specialized in transport, to study the differentiation of intestinal and kidney cells in vivo and in a human colon adenocarcinoma line HT29 in culture

A human villin cDNA clone to investigate the differentiation of intestinal and kidney cells in vivo and in culture

Nuclear processing of viral high-molecular-weight RNA in cells infected with herpes simplex virus type 1