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© Research
Publication : Biochimie

Protein phosphatase 2A as a new target for morphogenetic studies in the chick limb

Team: Archived: Nuclear Magnetic Resonance Of Biomolecules
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochimie - 01 Aug 2003

Viallet J, Garcia A, Weydert A

Link to Pubmed [PMID] – 14585542

Biochimie 2003 Aug;85(8):753-62

The family of ser/thr protein phosphatases 2A (PP2A) is a major regulator of cell proliferation and cell death and is critically involved in the maintenance of homeostasis. In order to analyse the importance of PP2A proteins in apoptotic and developmental processes, this review focuses on previous studies concerning the role of PP2A in morphogenesis. We first analyse wing formation in Drosophila, a model for invertebrates, then chick limb bud, a model for vertebrates. We also present a pioneer experiment to illustrate the potential relevance of PP2A studies in BMP signalling during chicken development and we finally discuss the BMP downstream signalling pathways.