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© Research
Publication : European journal of immunology

The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Jul 2002

Ayllón V, Cayla X, García A, Fleischer A, Rebollo A

Link to Pubmed [PMID] – 12115603

Eur. J. Immunol. 2002 Jul;32(7):1847-55

Bcl-xL and Bcl-w specifically interact with PP1alpha and Bad. A phosphatase activity sensitive to okadaic acid was detected in Bcl-xL, Bcl-w and Bad immunoprecipitates. Serine phosphorylation of Bcl-xL and Bcl-w correlates with the number of trimolecular complexes formed. Depletion of Bcl-xL and Bcl-w decreases the remaining Bad-associated phosphatase activity and association of protein phosphatase 1 (PP1)alpha to Bad. Bcl-xL and Bcl-w contain the R/K X V/I X F consensus motif shared by PP1 targeting subunits. This motif, in addition to F X X R X R motif, is involved in binding of Bcl-xL and Bcl-w to PP1alpha. Disruption of Bcl-xL/PP1alpha or Bcl-w/PP1alpha association strongly decreases Bad-associated phosphataseactivity and stability of trimolecular complexes. These results suggest that Bcl-xL and Bcl-w are PP1alpha targeting subunits and this trimolecular complex may be involved in the control of apoptosis.

http://www.ncbi.nlm.nih.gov/pubmed/12115603