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© Research
Publication : Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie

Wortmannin inhibits IGF-dependent differentiation in the mouse myogenic cell line C2

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie - 01 May 1997

Pinset C, Garcia A, Rousse S, Dubois C, Montarras D

Link to Pubmed [PMID] – 9239322

C. R. Acad. Sci. III, Sci. Vie 1997 May;320(5):367-74

Evidence has accumulated that suggests that insulin-like growth factors (IGFs) exert a positive influence on myoblast differentiation. We have undertaken to study the signalling events required for differentiation resulting from type-1 IGF receptor stimulation in C2 myoblasts, where autocrine production of IGF-II was abolished by means of antisense RNA. Exposure of the cells to IGFs leads to a rapid and sustained activation of phosphatidyl-inositol 3-kinase followed by the expression of Myod, myogenin and differentiation. The fungal metabolite, wortmannin, inhibits both PI 3-kinase and muscle differentiation with an IC 50 in the nanomolar range. IGFs are also known to cause a rapid activation of MAP kinase. However, the synthetic inhibitor of MEK, PD098059, which prevents MAP kinase activation, does not affect myoblast differentiation. These results provide evidence that PI 3-kinase, but not MAP kinase, is required for insulin-like growth factor receptor-dependent differentiation of muscle cells.

http://www.ncbi.nlm.nih.gov/pubmed/9239322