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© Research
Publication : European journal of immunology

Rho prevents apoptosis through Bcl-2 expression: implications for interleukin-2 receptor signal transduction

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Nov 1997

Gómez J, Martínez C, Giry M, García A, Rebollo A

Link to Pubmed [PMID] – 9394801

Eur. J. Immunol. 1997 Nov;27(11):2793-9

Here we describe a Rho-mediated apoptosis suppression pathway driven by Bcl-2 expression in the interleukin (IL)-4- or IL-2-dependent murine T cell line TS1 alpha beta. IL-2, but not IL-4, induces Bcl-2 expression through RhoA activation which is inhibited by the specific Rho family inhibitor, Clostridium difficile Toxin B, as well as by a dominant negative RhoA mutant. Using transient transfections of RhoA mutants tagged with the vesicular stomatitis virus glycoprotein, we show that a constitutively active RhoA mutant induces Bcl-2 expression and prevents apoptosis upon IL-4 withdrawal. Finally, we have identified the signaling pathway involved together with RhoA in Bcl-2 induction and show compelling evidence for the implication of phosphatidylinositol 3 kinase and protein kinase C.

http://www.ncbi.nlm.nih.gov/pubmed/9394801