Timeline

Florence Cordier

Permanent Researcher

02 Feb 2023

publication

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

01 Feb 2023

news

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

16 Mar 2022

event

Half-day Latest innovations and Applications in CryoEM& CryoET

01 Jan 2022

publication

Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7.

01 Oct 2021

publication

1 H, 15 N and 13 C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system

06 Nov 2020

publication

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

18 Aug 2020

publication

Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate.

17 Oct 2019

event

Department of Structural Biology and Chemisry seminar: Xavier Morelli, Integrated strategy for hit-to-lead optimization: the (Cova)DOTS approach (‘Diversity Oriented Target-focused Synthesis’)

23 May 2019

publication

Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches

26 Jan 2019

event

11th Conference “NMR: a tool for Biology”, 28-30 Jan 2019

05 Sep 2018

publication

Structural plasticity of the HHD2 domain of whirlin

28 Jun 2018

team

Biological NMR and HDX-MS Technological Platform

09 Mar 2018

publication

Tuning interval Branch-and-Prune for protein structure determination

08 Feb 2018

project

Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome

28 Sep 2017

publication

Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

01 Aug 2017

publication

Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery

09 Jul 2016

publication

(1)H, (13)C and (15)N backbone resonance assignments and dynamic properties of the PDZ tandem of Whirlin

31 May 2016

publication

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.

09 Sep 2015

tool

Nuclear Magnetic Resonance spectrometers

16 Jul 2015

team

Signalling and Molecular interactions

07 Jul 2015

project

Bacterial Transmembrane Signaling

11 May 2015

team

Structural Bioinformatics

05 May 2015

publication

Deciphering the unconventional peptide binding to the PDZ domain of MAST2

05 Mar 2015

publication

Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus.

18 Oct 2014

publication

Quantitative and dynamic analysis of PTEN phosphorylation by NMR

30 Sep 2014

publication

Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain.

07 Dec 2012

publication

Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR

14 Aug 2012

publication

Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN

12 Oct 2011

publication

Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death

29 Aug 2011

publication

Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension

19 Jan 2010

publication

Attenuation of rabies virulence: takeover by the cytoplasmic domain of its envelope protein

23 Oct 2009

publication

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

25 Nov 2008

publication

The zinc finger of NEMO is a functional ubiquitin-binding domain

30 Jan 2008

publication

Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation

01 Jan 2008

publication

Direct detection of N-H[…]O=C hydrogen bonds in biomolecules by NMR spectroscopy

01 Jan 2008

publication

Direct detection of N-H[…]N hydrogen bonds in biomolecules by NMR spectroscopy

07 Jul 2006

publication

DNA recognition by the brinker repressor–an extreme case of coupling between binding and folding

01 Aug 2005

publication

Nuclear magnetic resonance as a quantitative tool to study interactions in biomacromolecules

17 Dec 2004

publication

Insights into biomolecular hydrogen bonds from hydrogen bond scalar couplings

01 Sep 2004

publication

Quantitative comparison of the hydrogen bond network of A-state and native ubiquitin by hydrogen bond scalar couplings

01 Jul 2004

publication

Quantification of H/D isotope effects on protein hydrogen-bonds by h3JNC’ and 1JNC’ couplings and peptide group 15N and 13C’ chemical shifts

24 Dec 2003

publication

Direct observation of Calpha-Halpha…O=C hydrogen bonds in proteins by interresidue h3JCalphaC’ scalar couplings

12 Apr 2002

publication

Temperature-dependence of protein hydrogen bond properties as studied by high-resolution NMR

01 Jan 2001

publication

Scalar couplings across hydrogen bonds

01 Jan 2001

publication

An introduction to hydrogen bond scalar couplings

01 Dec 2000

publication

Ligand-induced strain in hydrogen bonds of the c-Src SH3 domain detected by NMR

15 Mar 2000

publication

Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain

01 Oct 1999

publication

Observation of through-hydrogen-bond 2hJHC’ in a perdeuterated protein

01 Jun 1999

publication

Measurement of 3hJNC’ connectivities across hydrogen bonds in a 30 kDa protein

17 Mar 1999

publication

Purple membrane induced alignment of biological macromolecules in the magnetic field

24 Feb 1999

publication

Direct observation of hydrogen bonds in proteins by interresidue (3h)J(NC ‘) scalar couplings

01 Feb 1999

publication

A doublet-separated sensitivity-enhanced HSQC for the determination of scalar and dipolar one-bond J-couplings

14 Aug 1998

publication

Solution structure, rotational diffusion anisotropy and local backbone dynamics of Rhodobacter capsulatus cytochrome c2

13 May 1998

publication

Precision and uncertainty in the characterization of anisotropic rotational diffusion by N-15 relaxation

01 Mar 1996

publication

Measurement of (13)C (α)- (13)CO cross-relaxation rates in (15)N-/ (13)C-labelled proteins

01 Nov 1995

publication

Determination of an initial set of NOE-derived distance constraints for the structure determination of N-15/C-13-labeled proteins

01 Feb 1995

publication

A little guide for advanced search:

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

Half-day Latest innovations and Applications in CryoEM& CryoET

Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7.

1 H, 15 N and 13 C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate.

Department of Structural Biology and Chemisry seminar: Xavier Morelli, Integrated strategy for hit-to-lead optimization: the (Cova)DOTS approach (‘Diversity Oriented Target-focused Synthesis’)

Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches

11th Conference “NMR: a tool for Biology”, 28-30 Jan 2019

Structural plasticity of the HHD2 domain of whirlin

Biological NMR and HDX-MS Technological Platform

Tuning interval Branch-and-Prune for protein structure determination

Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome

Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery

(1)H, (13)C and (15)N backbone resonance assignments and dynamic properties of the PDZ tandem of Whirlin

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.

Nuclear Magnetic Resonance spectrometers

Signalling and Molecular interactions

Bacterial Transmembrane Signaling

Structural Bioinformatics

Deciphering the unconventional peptide binding to the PDZ domain of MAST2

Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus.

Quantitative and dynamic analysis of PTEN phosphorylation by NMR

Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain.

Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR

Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN

Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death

Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension

Attenuation of rabies virulence: takeover by the cytoplasmic domain of its envelope protein

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

The zinc finger of NEMO is a functional ubiquitin-binding domain

Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation

Direct detection of N-H[…]O=C hydrogen bonds in biomolecules by NMR spectroscopy

Direct detection of N-H[…]N hydrogen bonds in biomolecules by NMR spectroscopy

DNA recognition by the brinker repressor–an extreme case of coupling between binding and folding

Nuclear magnetic resonance as a quantitative tool to study interactions in biomacromolecules

Insights into biomolecular hydrogen bonds from hydrogen bond scalar couplings

Quantitative comparison of the hydrogen bond network of A-state and native ubiquitin by hydrogen bond scalar couplings

Quantification of H/D isotope effects on protein hydrogen-bonds by h3JNC’ and 1JNC’ couplings and peptide group 15N and 13C’ chemical shifts

Direct observation of Calpha-Halpha…O=C hydrogen bonds in proteins by interresidue h3JCalphaC’ scalar couplings

Temperature-dependence of protein hydrogen bond properties as studied by high-resolution NMR

Scalar couplings across hydrogen bonds

An introduction to hydrogen bond scalar couplings

Ligand-induced strain in hydrogen bonds of the c-Src SH3 domain detected by NMR

Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain

Observation of through-hydrogen-bond 2hJHC’ in a perdeuterated protein

Measurement of 3hJNC’ connectivities across hydrogen bonds in a 30 kDa protein

Purple membrane induced alignment of biological macromolecules in the magnetic field

Direct observation of hydrogen bonds in proteins by interresidue (3h)J(NC ‘) scalar couplings

A doublet-separated sensitivity-enhanced HSQC for the determination of scalar and dipolar one-bond J-couplings

Solution structure, rotational diffusion anisotropy and local backbone dynamics of Rhodobacter capsulatus cytochrome c2

Precision and uncertainty in the characterization of anisotropic rotational diffusion by N-15 relaxation

Measurement of (13)C (α)- (13)CO cross-relaxation rates in (15)N-/ (13)C-labelled proteins

Determination of an initial set of NOE-derived distance constraints for the structure determination of N-15/C-13-labeled proteins

High-resolution 3D HNCOCA experiment applied to a 28 kDa paramagnetic protein