Nos activités de recherche sont orientées vers la caractérisation biochimique, biophysique et structurale de protéines impliquées dans la physiologie et la pathogénèse bactériennes, plus particulièrement dans les processus de signalisation.
Type II topoisomerases challenges
Biologie structurale d’enzymes et complexes métaboliques
Biologie de Cibles du Paludisme et Antipaludiques
Tuberculosis still remains a major threat for public health, with one-third of the world population latently infected, and more than one million deaths per year according to the WHO. Among the factors that have […]
ATPase inhibitors, the cases of human heat shock protein 90 and bacterial type IIA topoisomerases
Organic synthesis, still the limiting factor of Medicinal Chemistry? This ongoing project is based on our reviews (1-3) on the inhibitors of the ATPase functions of human heat shock protein 90 (HSP90) or […]
Structural studies of type II topoisomerases
Our main research projects focus on structural and functional studies of M. tuberculosis DNA gyrase and aim to understand the structural dynamics of DNA recognition by DNA gyrase and the quinolone resistance mechanisms […]
PknA/PknB in mycobacterial cell division
The genes pknA and pknB are located near the origin of replication in M. tuberculosis and are part of a conserved operon that also includes pstP (coding the only known Ser/Thr protein phosphatase […]
Envelope stress response
Our group, which has a long-term interest in protein folding, studies protein quality control systems in the periplasm of Escherichia coli.Our main objective is to understand the mechanism of misfolded protein sensing by the […]
Control of glutamate metabolism in mycobacteria
We recently demonstrated the existence of a phosphorylation-dependent control of glutamate metabolism in mycobacteria, in collaboration with H. O’Hare’s group in Leicester (O’Hare et al., 2008). Our results were supported by similar observations […]
2017PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis, PLoS Pathog. 2017 May;13(5):e1006399.
2016Modification in hydrophobic packing of HAMP domain induces a destabilization of the auto-phosphorylation site in the histidine kinase CpxA, Biopolymers 2016 Oct;105(10):670-82.
2016Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase, Cell Chem Biol 2016 Sep;.
2016Ser/Thr phosphorylation regulates the Fatty Acyl-AMP Ligase activity of FadD32, an essential enzyme in mycolic acid biosynthesis, J. Biol. Chem. 2016 Sep;.
2016Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis, J. Antimicrob. Chemother. 2016 May;.
2016Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria, J. Biol. Chem. 2016 Jul;291(27):13955-63.
2016Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors, Can. J. Chem. 2016, 94 , 240-250.
2015Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis, Structure 2016 Jan;24(1):92-104.
2015Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG, Chem. Biol. 2015 Jul;22(7):917-27.
2015Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis, Structure 2015 Jun;23(6):1039-48.
+Voir la liste complète de publications