Despite the conservation of central metabolism, an increasing amount of evidence indicates that there are unique features in Actinobacteria, one of the largest bacterial phyla that includes important human pathogens like Mycobacterium tuberculosis and […]
Tuberculosis still remains a major threat for public health, with one-third of the world population latently infected, and more than one million deaths per year according to the WHO. Among the factors that have […]
Acyl-CoAs are the major metabolic carriers of carbon in living organisms. The most conserved ways to their synthesis include the oxidative decarboxylation of α-ketoacids carried out by three distinct enzymatic machineries: the pyruvate dehydrogenase […]
PknA/PknB in mycobacterial cell division
The genes pknA and pknB are located near the origin of replication in M. tuberculosis and are part of a conserved operon that also includes pstP (coding the only known Ser/Thr protein phosphatase […]
Control of glutamate metabolism in mycobacteria
We recently demonstrated the existence of a phosphorylation-dependent control of glutamate metabolism in mycobacteria, in collaboration with H. O’Hare’s group in Leicester (O’Hare et al., 2008). Our results were supported by similar observations […]
2023High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase., Nat Commun 2023 Aug; 14(1): 4851.
2022Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase., Int J Mol Sci 2022 Sep; 23(19): .
2021Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex., Proc Natl Acad Sci U S A 2021 Nov; 118(48): .
2021A Tetratricopeptide Repeat Scaffold Couples Signal Detection to OdhI Phosphorylation in Metabolic Control by the Protein Kinase PknG., mBio 2021 Oct; 12(5): e0171721.
2021Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response., J Proteomics 2021 Jul; 244(): 104276.
2020Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design., J Med Chem 2020 07; 63(13): 7066-7080.
2020Structure-Based Drug Design for Tuberculosis: Challenges Still Ahead, Appl. Sci. 2020; 10(12):4248.
2020Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates., Front Chem 2020 ; 8(): 596187.
2019New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents., J Enzyme Inhib Med Chem 2019 Dec; 34(1): 823-828.
2019Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts., J Struct Biol 2019 11; 208(2): 182-190.
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