Biochimie des Protéines
La biochimie des protéines est une discipline sans cesse dynamisée par l’émergence de nouvelles technologies à la convergence de la chimie, la biophysique, la biologie moléculaire et la biologie cellulaire. Elle regroupe les méthodes […]
Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)
Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular […]
Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome
Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]
Rabies virus neuronal infection
We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]
Role of PDZ-binding motif from Flavivirus non-structural proteins in flaviviral life cycle
Arthropod-borne viruses (arboviruses) include numerous human and animal pathogens that are important global health threats. Flaviviruses are arboviruses belonging to the Flaviviridae family. They include neurotropic viruses such as West Nile (WNV), Japanese encephalitis […]
Nuclear Magnetic Resonance spectrometers
NMR spectroscopy 800 MHz NMR spectrometer installed in Pasteur Three NMR spectrometers with 11.7, 14 and 18 Tesla magnets (500 MHz, 600 MHz and 800Mhz), well suited for study of biomolecules are currently in […]
2021Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein., Sci Rep 2021 Jan; 11(1): 944.
2020Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis., Proc Natl Acad Sci U S A 2020 Nov; (): .
2020Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells., Sci Rep 2020 Oct; 10(1): 16430.
2020Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners., J Mol Biol 2020 Nov; 432(22): 5920-5937.
2019Structure-based optimization of a PDZ-binding motif within a viral peptide stimulates neurite outgrowth, J. Biol. Chem. 2019 Sep;294(37):13755-13768.
2019High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay, Methods Mol. Biol. 2019;2025:439-476.
2018Structural plasticity of the HHD2 domain of whirlin, FEBS J. 2018 10;285(20):3738-3752.
2018Tuning interval Branch-and-Prune for protein structure determination, J Glob Optim. 2018 Sep; 72(1):109–27.
2017Interfering peptides targeting protein-protein interactions: the next generation of drugs?, Drug Discov. Today 2018 Feb;23(2):272-285.
2017Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem, Structure 2017 11;25(11):1645-1656.e5.
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