Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)
Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular […]
Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome
Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]
Rabies virus neuronal infection
We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]
Role of PDZ-binding motif from Flavivirus non-structural proteins in flaviviral life cycle
Arthropod-borne viruses (arboviruses) include numerous human and animal pathogens that are important global health threats. Flaviviruses are arboviruses belonging to the Flaviviridae family. They include neurotropic viruses such as West Nile (WNV), Japanese encephalitis […]
Nuclear Magnetic Resonance spectrometers
NMR spectroscopy 800 MHz NMR spectrometer installed in Pasteur Three NMR spectrometers with 11.7, 14 and 18 Tesla magnets (500 MHz, 600 MHz and 800Mhz), well suited for study of biomolecules are currently in […]
2019Structure-based optimization of a PDZ-binding motif within a viral peptide stimulates neurite outgrowth, J. Biol. Chem. 2019 Sep;294(37):13755-13768.
2019High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay, Methods Mol. Biol. 2019;2025:439-476.
2018Structural plasticity of the HHD2 domain of whirlin, FEBS J. 2018 10;285(20):3738-3752.
2018Tuning interval Branch-and-Prune for protein structure determination, J Glob Optim. 2018 Sep; 72(1):109–27.
2017Interfering peptides targeting protein-protein interactions: the next generation of drugs?, Drug Discov. Today 2018 Feb;23(2):272-285.
2017Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem, Structure 2017 11;25(11):1645-1656.e5.
2015Quantifying domain-ligand affinities and specificities by high-throughput holdup assay, Nat. Methods 2015 Aug;12(8):787-93.
2015Deciphering the unconventional peptide binding to the PDZ domain of MAST2, Biochem. J. 2015 Jul;469(1):159-68.
2015Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus, Prog. Biophys. Mol. Biol. 2015 Oct;119(1):53-9.
2014Quantitative and dynamic analysis of PTEN phosphorylation by NMR, Methods 2015 May;77-78:82-91.
+Voir la liste complète de publications