Assistant Professor, CR IP (PhD 1992 Paris XI, HDR 2009 Paris VI), biochemist /biophysicist.
Biochimie des Protéines
La biochimie des protéines est une discipline sans cesse dynamisée par l’émergence de nouvelles technologies à la convergence de la chimie, la biophysique, la biologie moléculaire et la biologie cellulaire. Elle regroupe les méthodes […]
Impact of tissue components on cell migration: adhesion strength, cell morpho-dynamics and intracellular biophysics parameters.
We aim to analyze the impact of substrates on Entamoeba histolytica mode of migration during colonic mucosa invasion using live imaging and quantitative image analysis. E. histolytica, the etiological agent of amoebiasis, is a […]
Design and optimization of new bioluminescent systems better-suited to in cellulo and in vivo conditions
The use of light from the abyss in life sciences In the last decades, bioluminescent systems based on the expression of a luciferase and the addition of a luciferin to monitor the emission […]
Application of IL7-signaling research to guide diagnostic and therapeutic strategies
When the signaling induced by IL-7 is constitutively altered in patients, we observed lymphopenia when the response is reduced (eg AIDS), and leukemia when it is increased (eg acute lymphoblastic leukemia T-ALL). Comparing the […]
Basic Research – IL7 signaling in T-cells
With the technological support of facilities at the Pasteur Institute and through collaborations with several international institutions, we study the early steps of signaling induced by interleukin-7 on CD4 T lymphocytes (helper). This cytokine […]
2020High seroprevalence but short-lived immune response to SARS-CoV-2 infection in Paris., Eur J Immunol 2020 Dec; (): .
2020Core-modified coelenterazine luciferin analogues, synthesis and chemiluminescence properties., Chemistry 2020 Nov; (): .
2020A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples., Allergy 2020 May; (): .
2013Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells, J. Biol. Chem. 2013 Mar;288(12):8691-701.
2011Interleukin (IL)-2 and IL-15 have different effects on human natural killer lymphocytes, Hum. Immunol. 2011 Nov;72(11):1013-7.
2010KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain, J. Biol. Chem. 2011 Jan;286(1):707-16.
2010IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork, J. Mol. Biol. 2010 Nov;403(5):671-92.
2010Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding, Structure 2010 Jun;18(6):710-8.
2010Elucidation of the self-assembly pathway of lanreotide octapeptide into beta-sheet nanotubes: role of two stable intermediates, J. Am. Chem. Soc. 2010 Mar;132(12):4230-41.
2010Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response, J. Biol. Chem. 2010 May;285(20):14898-908.
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