Andres Alcover

La polypose adénomateuse familiale est une maladie caractérisée par l’apparition dans l’intestin de nombreux polypes susceptibles d‘évoluer en cancer en l’absence de prise en charge. Il s’agit d’une maladie génétique rare, le plus souvent […]

Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]

The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]

  Several laboratories showed that the molecular mechanism of T cell polarization and immunological synapse formation could be subverted by viruses that infect T lymphocytes, such as HIV-1 or HTLV-1, to better spread from […]

In order to concentrate at the immunological synapse, T cell receptor and signaling molecules that are evenly distributed throughout the cell need to be transported towards the antigen presenting cell contact zone and retained […]

 Signals generated by the engagement of the T cell antigen receptor are decoded and integrated by molecular complexes that form at the immunological synapse upon T cell receptor engagement. Assembly of these complexes, as […]

Antigen recognition by the T cell receptor triggers extensive rearrangements of both the actin and microtubule cytoskeleton. Cytoskeleton changes condition in turn morphological changes and molecular reorganization at the immunological synapse (Figure). We have […]