Andrés Alcover est Professeur à l’Institut Pasteur et directeur de l’Unité de Biologie Cellulaire des Lymphocytes à l’Institut Pasteur et de l’Unité Inserm 1221, Immunorégulation et Infection. Il a obtenu son doctorat de sciences à l’Universidad Autonoma de Madrid, Espagne, en 1982. Il a ensuite travaillé comme chercheur postdoctoral au Centro de Biologia Molecular à Madrid, puis au Dana-Farber Cancer Institute, Harvard Medical School, à Boston, USA. Il a rejoint l’Institut Pasteur comme chercheur statutaire à la fin 1987. Ses recherches portent sur les réponses immunes impliquant les lymphocytes T. Il s’intéresse aux mécanismes moléculaires responsables de l’activation de ces lymphocytes et à leur perturbations lors des infections virales ou au cours du développement de certains cancers.
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Présentation
Cours
Pasteur Course Advanced immunology
This intensive six-week course, including practical work, lectures, and scientific analysis workshops, covers the fundamental themes of cellular and molecular immunology. For more information and program, please, visit the course webpage.
2025-11-17 09:00:00
2026-01-09 18:00:00
Europe/Paris
Pasteur Course Advanced immunology
This intensive six-week course, including practical work, lectures, and scientific analysis workshops, covers the fundamental themes of cellular and molecular immunology. For more information and program, please, visit the course webpage.
Institut Pasteur, Rue du Docteur Roux, Paris, France
Projets Transversaux
Projets
Anciennes Équipes
Publications
Télécharger-
2024Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids, Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (11), pp.e2316500121. ⟨10.1073/pnas.2316500121⟩.
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2023T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations, Frontiers in Immunology, 2023, 14, pp.1163466. ⟨10.3389/fimmu.2023.1163466⟩.
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2022The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration., Sci Adv 2022 Apr; 8(15): eabl5942.
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2021Cell Polarity Regulators, Multifunctional Organizers of Lymphocyte Activation and Function., Biomed J 2021 Oct; (): .
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2020Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions., Front Cell Dev Biol 2020 ; 8(): 591348.
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2020Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions., Immunohorizons 2020 06; 4(6): 363-381.
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2020ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation., Cell Rep 2020 Mar; 30(10): 3434-3447.e6.
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2018HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions., J. Immunol. 2018 11; 201(9): 2624-2640.
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2018Cell Biology of T Cell Receptor Expression and Regulation., Annu. Rev. Immunol. 2018 04; 36(): 103-125.
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2017Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization., Cell Rep 2017 Oct; 21(1): 181-194.
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