Andrés Alcover, Professor at the Institut Pasteur, is currently the Head of the Lymphocyte Cell Biology Unit at the Insitut Pasteur and the Director of the INSERM Unit-1221, Immunomodulation and Infection. He got his PhD degree at the Universidad Autonoma, Madrid, Spain in 1982. He further trained as a postdoctoral fellow at the Center of Molecular Biology in Madrid and at the Dana-Farber Cancer Institute, Harvard Medical School in Boston MA, USA. He joined the Institut Pasteur as a staff scientist at the end of 1987. His main research interest for many years has been the molecular mechanisms that control T lymphocyte activation and their subversion by retroviruses that infect T lymphocytes.
CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie
Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]
Think tank: Cancer
The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
The “virus biofilm”: a new mode of virus cell-to-cell transmission
Several laboratories showed that the molecular mechanism of T cell polarization and immunological synapse formation could be subverted by viruses that infect T lymphocytes, such as HIV-1 or HTLV-1, to better spread from […]
Intracellular vesicle traffic drives immunological synapse formation and T cell activation. Modulation by human immunodeficiency virus (HIV-1)
In order to concentrate at the immunological synapse, T cell receptor and signaling molecules that are evenly distributed throughout the cell need to be transported towards the antigen presenting cell contact zone and […]
How the dynamics of signaling complexes at the immunological synapse controls T cell activation
Signals generated by the engagement of the T cell antigen receptor are decoded and integrated by molecular complexes that form at the immunological synapse upon T cell receptor engagement. Assembly of these complexes, as […]
Role of cytoskeleton in the formation of the immunological synapse and in T cell activation
Antigen recognition by the T cell receptor triggers extensive rearrangements of both the actin and microtubule cytoskeleton. Cytoskeleton changes condition in turn morphological changes and molecular reorganization at the immunological synapse (Figure). We have […]
2018HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions, J. Immunol. 2018 Nov;201(9):2624-2640.
2017Cell Biology of T Cell Receptor Expression and Regulation, Annu. Rev. Immunol. 2017 Dec;.
2017Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization, Cell Rep 2017 Oct;21(1):181-194.
2017Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction, J. Immunol. 2017 Apr;198(7):2967-2978.
2017Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function, PLoS ONE 2017;12(1):e0170396.
2017Studying the Immune Synapse in HIV-1 Infection, Methods Mol. Biol. 2017;1584:545-557.
2017Imaging Vesicular Traffic at the Immune Synapse, Methods Mol. Biol. 2017;1584:129-142.
2016The functional interplay of Rab11, FIP3 and Rho proteins on the endosomal recycling pathway controls cell shape and symmetry, Small GTPases 2016 Aug;:1-6.
2016Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation, EMBO J. 2016 Jun;35(11):1160-74.
2015Immunological Synapse, eLS John Wiley & Sons, Ltd: Chichester DOI: 10.1002/9780470015902.a0004027.pub2.
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