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© Andres Alcover
Scanning electron microscopy showing a conjugate formed between a T lymphocyte and an antigen presenting cell. It is worth noting the long shape of the T cell (Tc) polarized towards the antigen presenting cell (APC) and the membrane protrusions that adhere the T lymphocyte to the antigen presenting cell.

About

Andrés Alcover, Professor at the Institut Pasteur, is currently the Head of the Lymphocyte Cell Biology Unit at the Insitut Pasteur and the Director of the INSERM Unit-1221, Immunomodulation and Infection. He got his PhD degree at the Universidad Autonoma, Madrid, Spain in 1982. He further trained as a postdoctoral fellow at the Center of Molecular Biology in Madrid and at the Dana-Farber Cancer Institute, Harvard Medical School in Boston MA, USA. He joined the Institut Pasteur as a staff scientist at the end of 1987. His main research interest for many years has been the molecular mechanisms that control T lymphocyte activation and their subversion by retroviruses that infect T lymphocytes.

Projects

project
Ongoing
9 Members

Projet de Recherche Clinique : Impact des mutations du gène APC (Adenomatous polyposis coli) dans les réponses immunes anti-tumorales

Andres Alcover (PI)

La polypose adénomateuse familiale est une maladie caractérisée par l’apparition dans l’intestin de nombreux polypes susceptibles d‘évoluer en cancer en l’absence de prise en charge. Il s’agit d’une maladie génétique rare, le plus souvent […]
project
Ongoing
18 Members

CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie

Hélène Laude (PI)

Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]
project
Ongoing
10 Members

Think tank: Cancer

Ludovic Deriano (PI)

The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
project
Completed
6 Members

The “virus biofilm”: a new mode of virus cell-to-cell transmission

Andres Alcover (PI)

  Several laboratories showed that the molecular mechanism of T cell polarization and immunological synapse formation could be subverted by viruses that infect T lymphocytes, such as HIV-1 or HTLV-1, to better spread from […]
project
Ongoing
5 Members

Intracellular vesicle traffic drives immunological synapse formation and T cell activation. Modulation by human immunodeficiency virus (HIV-1)

Andres Alcover (PI)

In order to concentrate at the immunological synapse, T cell receptor and signaling molecules that are evenly distributed throughout the cell need to be transported towards the antigen presenting cell contact zone and retained […]
project
Ongoing
4 Members

How the dynamics of signaling complexes at the immunological synapse controls T cell activation

Vincenzo Di Bartolo (PI)

 Signals generated by the engagement of the T cell antigen receptor are decoded and integrated by molecular complexes that form at the immunological synapse upon T cell receptor engagement. Assembly of these complexes, as […]
project
Ongoing
11 Members

Cytoskeleton, immunological synapse and T cell activation: role of Ezrin and Adenomatous polyposis coli

Andres Alcover (PI)

Antigen recognition by the T cell receptor triggers extensive rearrangements of both the actin and microtubule cytoskeleton. Cytoskeleton changes condition in turn morphological changes and molecular reorganization at the immunological synapse (Figure). We have […]

Publications

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