Andrés Alcover, Professor at the Institut Pasteur, is currently the Head of the Lymphocyte Cell Biology Unit at the Insitut Pasteur and the Director of the INSERM Unit-1221, Immunomodulation and Infection. He got his PhD degree at the Universidad Autonoma, Madrid, Spain in 1982. He further trained as a postdoctoral fellow at the Center of Molecular Biology in Madrid and at the Dana-Farber Cancer Institute, Harvard Medical School in Boston MA, USA. He joined the Institut Pasteur as a staff scientist at the end of 1987. His main research interest for many years has been the molecular mechanisms that control T lymphocyte activation and their subversion by retroviruses that infect T lymphocytes.
Think tank: Cancer
The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
The “virus biofilm”: a new mode of virus cell-to-cell transmission
Several laboratories showed that the molecular mechanism of T cell polarization and immunological synapse formation could be subverted by viruses that infect T lymphocytes, such as HIV-1 or HTLV-1, to better spread from […]
Intracellular vesicle traffic drives immunological synapse formation and T cell activation. Modulation by human immunodeficiency virus (HIV-1)
In order to concentrate at the immunological synapse, T cell receptor and signaling molecules that are evenly distributed throughout the cell need to be transported towards the antigen presenting cell contact zone and […]
How the dynamics of signaling complexes at the immunological synapse controls T cell activation
Signals generated by the engagement of the T cell antigen receptor are decoded and integrated by molecular complexes that form at the immunological synapse upon T cell receptor engagement. Assembly of these complexes, as […]
Role of cytoskeleton in the formation of the immunological synapse and in T cell activation
Antigen recognition by the T cell receptor triggers extensive rearrangements of both the actin and microtubule cytoskeleton. Cytoskeleton changes condition in turn morphological changes and molecular reorganization at the immunological synapse (Figure). We have […]
2017Cell Biology of T Cell Receptor Expression and Regulation, Annu. Rev. Immunol. 2017 Dec;.
2017Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization, Cell Rep 2017 Oct;21(1):181-194.
2017Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction, J. Immunol. 2017 Apr;198(7):2967-2978.
2017Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function, PLoS ONE 2017;12(1):e0170396.
2017Studying the Immune Synapse in HIV-1 Infection, Methods Mol. Biol. 2017;1584:545-557.
2017Imaging Vesicular Traffic at the Immune Synapse, Methods Mol. Biol. 2017;1584:129-142.
2016The functional interplay of Rab11, FIP3 and Rho proteins on the endosomal recycling pathway controls cell shape and symmetry, Small GTPases 2016 Aug;:1-6.
2016Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation, EMBO J. 2016 Jun;35(11):1160-74.
2015Immunological Synapse, eLS John Wiley & Sons, Ltd: Chichester DOI: 10.1002/9780470015902.a0004027.pub2.
2015Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype, PLoS Pathog. 2015 May;11(5):e1004838.
+View full list of publications