Timeline

Aziz El Amraoui
Head of Structure
09 Jul 2018
publication
Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome
Read more12 Feb 2018
31 Jan 2018
publication
Cone degeneration is triggered by the absence of USH1 proteins but prevented by antioxidant treatments
Read more01 Dec 2017
publication
CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival
Read more19 Oct 2017
18 Oct 2017
11 May 2017
publication
Usher syndrome type 1-associated cadherins shape the photoreceptor outer segment
Read more20 Apr 2017
event
“A Spectrin-bound phosphatase bridges Crumbs-mediated polarity and Hippo-mediated growth” – Dr Graham Thomas
Read more08 Feb 2017
publication
Spectrin βV adaptive mutations and changes in subcellular location correlate with emergence of hair cell electromotility in mammalians
Read more20 Oct 2016
18 Aug 2016
publication
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease
Read more27 Jul 2016
publication
An innovative strategy for the molecular diagnosis of Usher syndrome identifies causal biallelic mutations in 93% of European patients
Read more11 Jan 2016
publication
Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth
Read more19 Nov 2015
19 Nov 2015
16 Jul 2015
19 Oct 2014
publication
Successful gene therapy in the RPGRIP1-deficient dog: a large model of cone-rod dystrophy
Read more16 Sep 2014
11 Jun 2014
publication
An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells
Read more20 Mar 2014
publication
The retinal phenotype of Usher syndrome: pathophysiological insights from animal models
Read more23 May 2013
publication
The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route
Read more01 Jan 2013
20 Oct 2012
publication
Gene and cell therapies to listen to the inner ear | Les thérapies génique et cellulaire à l’écoute de l’oreille interne
Read more20 Oct 2012
01 Feb 2012
publication
Usher syndrome (sensorineural deafness and retinitis pigmentosa): pathogenesis, molecular diagnosis and therapeutic approaches
Read more01 Jan 2012
01 Nov 2010
01 Jan 2010
01 Jun 2009
publication
The outer hair cell of the mammalian cochlea: An outstanding amplifier | La cellule ciliée externe de la cochlée des mammifères: Un amplificateur aux propriétés exceptionnelles
Read more01 Feb 2009
20 Oct 2008
16 Sep 2008
publication
alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells
Read more31 Jul 2007
publication
Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions
Read more21 Nov 2005
publication
Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells
Read more15 Oct 2005
publication
Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells
Read more01 Aug 2005
publication
[Usher syndrome type I and the differentiation of inner ear sensory cells’ hair bundles]
Read more01 Jul 2005
publication
PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa
Read more08 Dec 2004
08 Dec 2004
publication
Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly
Read more15 Apr 2004
publication
Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells.
Read more01 Mar 2003
publication
Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin
Read more18 Apr 2002
publication
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes
Read more01 Aug 2001
publication
Spatiotemporal expression of otogelin in the developing and adult mouse inner ear
Read more15 Nov 2000
publication
Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex.
Read more22 Sep 2000
11 Apr 2000
publication
KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway
Read more01 Feb 2000
01 Apr 1999
publication
A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafness
Read more05 Feb 1999
publication
KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
Read more01 Dec 1998
publication
Eya1 expression in the developing ear and kidney: towards the understanding of the pathogenesis of Branchio-Oto-Renal (BOR) syndrome
Read more23 Dec 1997
20 Oct 1997
15 Oct 1997
01 Aug 1997
01 Mar 1997
publication
Cloning of the genes encoding two murine and human cochlear unconventional type I myosins
Read more23 Dec 1996
publication
Comigration of tyrosine hydroxylase- and gonadotropin-releasing hormone-immunoreactive neurons in the nasal area of human embryos
Read more01 Aug 1996
publication
Human Usher 1B/mouse shaker-1: the retinal phenotype discrepancy explained by the presence/absence of myosin VIIA in the photoreceptor cells
Read more16 Apr 1996
publication
Human myosin VIIA responsible for the Usher 1B syndrome: a predicted membrane-associated motor protein expressed in developing sensory epithelia
Read more01 May 1995
publication
Interactions between adenohypophyseal, hypothalamic and nasal presumptive territories during early neurulation process
Read more01 Dec 1993
publication
Experimental evidence for the early commitment of the presumptive adenohypophysis
Read more01 Jun 1993
publication