Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
Starting Date
01
Nov 2015
Ending Date
31
Oct 2020
Status
Ongoing
Members
2
Structures
3

About

The enlightenment of the deafness: an holistic approach of Usher syndrome

Recherche Hospitalo-Universitaire en Santé

Professor Christine Petit (Institut Pasteur, Collège de France, Inserm, UPMC) and Dr. Aziz El-Amraoui (Institut Pasteur, Inserm, UPMC) coordinate the part devoted to hearing in the LIGHT4DEAF project (coordinated by Professor José-Alain Sahel, Institut de la vision, Inserm, UPMC,CNRS). LIGHT4DEAF is designed to implement a major, concerted and interdisciplinary effort between scientists, ENT specialists, ophthalmologists and human sciences, vestibular and neuro-cognitive experts in order to fulfil unmet USH patients’ clinical needs.  

            Blindness and deafness are the two most prevalent sensory impairments, each of which profoundly impacts the life of the affected person, whether child or adult. As a most ambitious goal, perfectly fitting the scope of our DHU “Vision and Handicaps”, LIGHT4DEAF aims at tackling Usher syndrome (USH), the most common form of combined deaf-blindness, often associated with vestibular defects. Professor Christine Petit leads the research on the genetic bases and the pathogenesis of this syndrome since her finding of the first causative twenty years ago.

            Clinical centres in the LIGHT4DEAF consortium have developed and will continue to improve a reliable, early molecular diagnosis and protocols for full clinical characterisation of USH symptoms, which will be valuable for the foreseen USH clinical trials. LIGHT4DEAF also aims at fighting sensory impairments caused by USH through the preservation or restoration of visual functions (corrective gene therapy, neuroprotection, retinal prostheses and optogenetics), the restoration of auditory functions (gene therapy, pharmacology and cochlear implants) for the USH forms with progressive hearing loss and the improvement of balance performances (sensory substitution prostheses). These will be tested on appropriate animal models and will lead to clinical trials relying on a morpho-functional characterization of the defective photoreceptor and auditory sensory cells. The effect of these therapies on the severity of the impairments will be analyzed in the overall context of visual compensation for cochlear deficits as well as vestibular deficits. A quantified real-life approach of such interactions is proposed.

Fundings