Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Laboratory /

Progressive Sensory Disorders, PathoPhysiology and Therapy

Department of Neuroscience

About

Over the last years, research on the inner ear and retinal sensory systems has become, in many cases, a blueprint for aspects pertinent to the nervous system and related neurodegenerative disorders. The senses of vision, balance, and hearing (Fig. 1) are essential for every significant activity of daily life, ranging from social interactions and mobility to an appreciation of music, art, and nature. Consequently, impairment of these sensory modalities has a profound negative impact in the quality of life of the affected individuals, which range from communication constraints and lower access to entertainment and working opportunities. In turn, this can lead to social isolation and depression 1-5. From comprehensive empirical data, the World Health Organization estimates that around 285 million people currently display severe vision impairments worldwide (see http://www.who.int/). Also, 460 million people — representing 5% of the world’s population — have a disabling hearing impairment (with or without balance deficit). This number is expected to increase to more than one billion people by 2050 (see http://www.who.int/). Altogether, these sensory deficits have a dramatic economic impact on healthcare systems and society as a whole.

Over the years, we showed that, even though processing different sensory signals — mechanical stimulation in hair cells and light inputs in photoreceptors—, the inner ear and retinal sensory cells both display membrane- and cytoskeleton-based structures that are key to hearing, balance and vision functioning (Fig. 1). The research interests of our lab span the inner ear and the retinal sensory systems, from animal model to human patients, from normal to abnormal function, from organ architecture to behavior, and from the molecular and genetic bases of hearing, balance, and/or vision deficits to innovative treatments solutions.

The Progressive Sensory Disorders (PSD) team is designed to bring together all necessary knowledge, ranging from tissue engineering & animal modeling, molecular & cellular biology, “Omics”, biochemistry and computational networks analyses, imaging, and physiology techniques. Our research goals are:

(1) understand and elucidate the way the sound-receptive and the light-sensitive sensory cells and neurons are tuned to the specific needs of corresponding sensory modalities, in normal and disease conditions.

(2) identify sensitive/specific disease markers and potential external & environmental risk factors (light- or noise-exposure, oxidative stress, age, …), and provide better predictions of disease progression & severity.

(3) develop and evaluate efficacy of innovative gene replacement therapies & gene editing mutation repair strategies to prevent, protect against, and/or correct Usher sense deficits, a prelude to future clinical trials.

Our projects call for multidisciplinary and integrative approaches, taking advantage of multiple internal, national and international collaborations. The lab is staffed by a dynamic team, with three permanent staff members, 2 Assistant Professors (Sedigheh Delmaghani and Sandrine Vitry) and a senior Technician (Sylvie Nouaille), working along with post-doctoral fellows, PhD, undergraduate and graduate students.

Recent team achievements, brief biographies of current lab members, list of former members, images of inner ear tissue, publications involving team members are indicated below.

If you want to join the team or have questions about our work, please feel free to contact us

(aziz.el-amraoui@pasteur.fr or PSD-PI@pasteur.fr).

Thank you for visiting our website

Figure 1: Similarities between the sensory organs of hearing & balance (A), and vision (B). In absence of a cure, untreated decline of vision, balance and/or hearing have huge economic & societal impact worldwide. Whatever the cause – i.e., genetic, environment (noise, ototoxic drugs, light-phototoxicity, …), or aging – loss of hearing, balance, and/or vision is often linked to irreversible loss of the specialized sensory cells in the inner ear (hair cells) and the eye (photoreceptors), and associated neurons. We study disorders targeting these sensory cells as model systems to tackle neurodegenerative disorders from disease mechanisms to therapeutic options.

Summaries of some last achievements (2015-2020) :  https://research.pasteur.fr/wp-content/uploads/2015/07/research_pasteur-enprogressive-sensory-disorders-pathophysiology-and-therapyfrdeficits-sensoriels-progressifs-pathophysiologie-et-therapie-psd-lab-achievements-2015-2020.pdf

CV (2 pages):  https://research.pasteur.fr/wp-content/uploads/2015/05/research_pasteur-aziz-el-amraoui-cv-el-amraoui-2017.pdf

List of publications: https://research.pasteur.fr/wp-content/uploads/2015/05/research_pasteur-aziz-el-amraoui-el-amraoui-list-of-publications-2017.pdf

 

 

Former Members

2000
2000
Name
Position
2015
2020
Matteo Cortese
PhD Student
2015
2020
Chiara Benedetto
Research Engineer
2020
2020
Ana Mesic
Master Student

Projects

Fundings

Partners

Publications

Download

Annoucement : OMI Pasteur 2021 Course

We are pleased to announce the OMI Pasteur 2021 course “Neurological and sensory disorders: genes, pathogenesis & innovative therapies”, which will be held in Salzburg on March 07-13, 2021.

This OMI Pasteur course aims to promote an international exchange on fundamental and medical knowledge and advancements in the field of sensorineural degenerative disorders:

– How our brain and sensory organs work, what happens when either system fails

– Impact of ageing and external factors on our senses and cognition

– Conventional and innovative therapies to the sensory and neurological disorders

For further informations :

https://www.pasteur.fr/pasteur-course/Neurological and sensory disorders: genes, pathogenesis & innovative therapies

Contact

Phone: 33 1 76 53 50 64 Email: aziz.el-amraoui@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France