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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
01
Oct 2017
Ending Date
30
Sep 2021
Status
Ongoing
Members
3
Structures
2

About

Hearing impairment, the most frequent sensory deficit, has a dramatic economic impact on healthcare systems worldwide. The HearInNoise project will be focused on late onset and progressive hearing impairment, more amenable to therapy but for which the underlying mechanisms remain unclear. Using mutant mice affected by progressive deafness as entry points, and using cutting edge approaches in biochemistry, cell biology, imaging, and physiology, our aims are to: i) disentangle the mechanisms and contribution of the hair cells and/or auditory neurons to the disease, ii) identify new key actors in the pre- and post-synapse organization and functioning, iii) study the impact of environment and/or age on severity of some deafness forms, and iv) implement innovative ear delivery approaches to slow down or halt hearing deterioration. Scientific, technical, and medical progresses are expected, creating promising therapeutic tools with potential applications to other forms of neurodegenerative disorders.

Fundings