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© Research
Publication :

The outer hair cell of the mammalian cochlea: An outstanding amplifier | La cellule ciliée externe de la cochlée des mammifères: Un amplificateur aux propriétés exceptionnelles

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in - 01 Jun 2009

Kirian Legendre, Christine Petit et Aziz El-Amraoui*

Med Sci (Paris) 2009 ; 25 : 117–120

La cochlée, organe auditif des mammifères, tire sa sensibilité et sa sélectivité en fréquence de la présence des cellules ciliées externes (CCE). Ces cellules, qui n’existent que chez les mammifères, sont dotées d’électromotilité, c’est-à-dire que leur membrane plasmique latérale se contracte ou s’allonge en réponse à des modifications du champ électrique. C’est la prestine, une protéine intégrale de la membrane, qui confère aux CCE cette propriété. Le long de la paroi latérale, un treillis cortical hautement organisé, constitué d’actine et de spectrine, contribue également à ce processus. Nous venons de montrer que la sous-unité βV (et non l’isoforme βII) constitue, avec la sous-unité aII, la spectrine de la paroi des CCE, et qu’elle interagirait indirectement avec la prestine. La nature moléculaire du lien qui unit ces deux protéines reste à déterminer.

https://www.scopus.com/record/display.uri?eid=2-s2.0-60149085248&origin=inward&txGid=06cd457bef2ca80dbf63e557ea10def8