Timeline

Undine Mechold

Group Leader

25 Sep 2023

publication

Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin

16 Nov 2021

publication

Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens.

26 Mar 2020

team

Group : Actin-activated nucleotidyl cyclases

12 Nov 2018

publication

Differential regulation of actin-activated nucleotidyl cyclase virulence factors by filamentous and globular actin

30 Oct 2018

publication

The extreme C terminus of the effector ExoY is crucial for binding to its eukaryotic activator, F-actin

05 Sep 2018

event

PhD thesis: ExoY, une toxine nucléotidyl cyclase de Pseudomonas aeruginosa

16 Dec 2017

publication

ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview

13 Mar 2017

event

Ina Attrée seminar

05 Dec 2016

publication

Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins

24 Aug 2015

publication

Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa

08 Jul 2015

project

Regulatory roles of signaling Nucleotides

11 May 2015

team

Biochemistry of Macromolecular Interactions

23 Jan 2014

publication

Two-step synthesis and hydrolysis of cyclic di-AMP in Mycobacterium tuberculosis

25 Apr 2013

publication

Differential regulation by ppGpp versus pppGpp in Escherichia coli

15 Apr 2012

publication

3′-5′ phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo

19 Jan 2012

publication

Identification of a novel nanoRNase in Bartonella

23 Nov 2011

publication

Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae

01 Nov 2009

publication

Analysis of interaction partners of H4 histone by a new proteomics approach

24 Jun 2009

publication

Degradation of nanoRNA is performed by multiple redundant RNases in Bacillus subtilis

15 Sep 2008

publication

Multiple displacement amplification for complex mixtures of DNA fragments

22 Jun 2007

publication

YtqI from Bacillus subtilis has both oligoribonuclease and pAp-phosphatase activity

01 Jul 2006

publication

Analysis of human histone H2AZ deposition in vivo argues against its direct role in epigenetic templating mechanisms

08 May 2006

publication

Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells

17 Jan 2005

publication

Codon optimization of the BirA enzyme gene leads to higher expression and an improved efficiency of biotinylation of target proteins in mammalian cells

01 Apr 2004

publication

Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected]

01 Feb 2004

publication

Use of protein biotinylation in vivo for chromatin immunoprecipitation

02 Dec 2003

publication

Inducible expression, enzymatic activity, and origin of higher plant homologues of bacterial RelA/SpoT stress proteins in Nicotiana tabacum

01 Jun 2002

publication

Intramolecular regulation of the opposing (p)ppGpp catalytic activities of Rel(Seq), the Rel/Spo enzyme from Streptococcus equisimilis

01 Jul 1998

publication

The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism

01 Apr 1997

publication

Characterization of the stringent and relaxed responses of Streptococcus equisimilis

01 Jan 1997

publication

Elicitation of high (p)ppGpp levels in Streptococcus equisimilis without imposing nutritional deprivation

01 Mar 1996

publication

Functional analysis of a relA/spoT gene homolog from Streptococcus equisimilis

01 Jan 1995

publication

The streptokinase gene: allelic variation, genomic environment and expression control

01 Feb 1994

publication

Inactivation of the streptokinase gene prevents Streptococcus equisimilis H46A from acquiring cell-associated plasmin activity in the presence of plasminogen

01 Oct 1993

publication

A little guide for advanced search:

Timeline

Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin

Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens.

Group : Actin-activated nucleotidyl cyclases

Differential regulation of actin-activated nucleotidyl cyclase virulence factors by filamentous and globular actin

The extreme C terminus of the effector ExoY is crucial for binding to its eukaryotic activator, F-actin

PhD thesis: ExoY, une toxine nucléotidyl cyclase de Pseudomonas aeruginosa

ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview

Ina Attrée seminar

Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins

Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa

Regulatory roles of signaling Nucleotides

Biochemistry of Macromolecular Interactions

Two-step synthesis and hydrolysis of cyclic di-AMP in Mycobacterium tuberculosis

Differential regulation by ppGpp versus pppGpp in Escherichia coli

3′-5′ phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo

Identification of a novel nanoRNase in Bartonella

Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae

Analysis of interaction partners of H4 histone by a new proteomics approach

Degradation of nanoRNA is performed by multiple redundant RNases in Bacillus subtilis

Multiple displacement amplification for complex mixtures of DNA fragments

YtqI from Bacillus subtilis has both oligoribonuclease and pAp-phosphatase activity

Analysis of human histone H2AZ deposition in vivo argues against its direct role in epigenetic templating mechanisms

Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells

Codon optimization of the BirA enzyme gene leads to higher expression and an improved efficiency of biotinylation of target proteins in mammalian cells

Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected]

Use of protein biotinylation in vivo for chromatin immunoprecipitation

Inducible expression, enzymatic activity, and origin of higher plant homologues of bacterial RelA/SpoT stress proteins in Nicotiana tabacum

Intramolecular regulation of the opposing (p)ppGpp catalytic activities of Rel(Seq), the Rel/Spo enzyme from Streptococcus equisimilis

The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism

Characterization of the stringent and relaxed responses of Streptococcus equisimilis

Elicitation of high (p)ppGpp levels in Streptococcus equisimilis without imposing nutritional deprivation

Functional analysis of a relA/spoT gene homolog from Streptococcus equisimilis

The streptokinase gene: allelic variation, genomic environment and expression control

Inactivation of the streptokinase gene prevents Streptococcus equisimilis H46A from acquiring cell-associated plasmin activity in the presence of plasminogen

Genetic organization of the streptokinase region of the Streptococcus equisimilis H46A chromosome