Timeline

Pierre Bruhns

Head of Structure

19 Jan 2024

publication

A monoclonal antibody collection for C.difficile typing ?

01 Jan 2024

publication

Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology.

29 Nov 2023

event

4 X Quart d’heure Pasteur-médecine “CURARES en anesthésie – allergies et thérapies”

25 Aug 2023

publication

A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.

10 Jul 2023

publication

Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics.

06 Apr 2023

publication

Conditional neutrophil depletion challenges their contribution to mouse models of anaphylaxis.

13 Mar 2023

news

New publication – A vaccine targeting human IL-4 and IL-13 protects against asthma in humanized mice

17 Feb 2023

publication

A vaccine targeting human IL-4 and IL-13 protects against asthma in humanized mice.

01 Jan 2023

publication

Isolation methods determine human neutrophil responses after stimulation.

03 May 2022

publication

High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura.

08 Feb 2022

publication

Specificity of mouse and human Fcgamma receptors and their polymorphic variants for IgG subclasses of different species.

03 Sep 2021

publication

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome

11 May 2021

publication

Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice.

01 Sep 2020

project

Understanding protective humoral immunity in asymptomatic dengue-infected individuals

17 Dec 2019

event

Antibodies as Drugs 2022 (Keystone Symposia)

06 Nov 2019

publication

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

10 Jul 2019

publication

An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis

14 Feb 2019

team

U1222 – Humoral Immunity

14 Jan 2019

event

Antibodies and Complement conference 2023

07 Nov 2018

project

High throughput selection of nanobodies by droplet based microfluidics (PTR nanofluidic)

04 Jun 2018

event

Cellular stress and control of inflammation in autoimmune disease and cancer

13 Apr 2018

publication

Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.

20 Oct 2017

publication

Low end-tidal CO2 as a real-time severity marker of intra-anaesthetic acute hypersensitivity reactions.

11 Sep 2017

publication

Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring

17 Feb 2017

publication

Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide

10 Oct 2016

publication

In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.

24 Aug 2016

publication

Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice.

26 Apr 2016

publication

IgG subclasses determine pathways of anaphylaxis in mice

27 Oct 2015

project

Microfluidics@Pasteur

26 Oct 2015

publication

Mouse and human FcR effector functions.

22 Oct 2015

project

ERC-2013-CoG – 616050_MyeloSHOCK – Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples

21 Oct 2015

project

DROPmAbs – Deep-mining of antibody repertoires using droplet-based microfluidics combined with barcoded deep sequencing for diagnostics and therapeutic antibody discovery

20 Oct 2015

project

Role of platelets and their interactions in allergic diseases

19 Oct 2015

project

Clinical and pathological consequences of human anti-drug antibodies (NASA study)

18 Oct 2015

project

Developing novel models of disease and vaccination in Ab- and FcR-humanized mice

17 Oct 2015

project

Antibody-based anti-tumor immunotherapy

01 Sep 2015

patent

METHODS FOR INHIBITING MAST CELL ACTIVATION AND TREATING MAST CELL-DEPENDENT INFLAMMATORY DISEASES AND DISORDERS USING LACTOBACILLUS

01 Sep 2015

patent

USE OF ANTl-FcyRI AND/OR ANTl-FcyRllA ANTIBODIES FOR TREATING ARTHRITIS, INFLAMMATION, THROMBOCYTOPENIA AND ALLERGIC SHOCK

27 May 2015

publication

Shaping mycolactone for therapeutic use against inflammatory disorders.

11 May 2015

team

Antibodies in Therapy and Pathology

17 Oct 2014

publication

Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization

30 Jul 2014

publication

A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy

25 Jul 2014

publication

Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis

30 May 2014

publication

Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies

21 Jan 2014

publication

The function of Fcγ receptors in dendritic cells and macrophages

26 Aug 2013

publication

Neutrophils mediate antibody-induced antitumor effects in mice

26 Mar 2013

publication

Neutrophils in local and systemic antibody-dependent inflammatory and anaphylactic reactions

04 Jan 2013

publication

The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy

03 Dec 2012

publication

Quorum sensing contributes to activated IgM-secreting B cell homeostasis

12 Nov 2012

publication

Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma

01 Sep 2012

publication

A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia

20 Aug 2012

publication

Autonomous phagosomal degradation and antigen presentation in dendritic cells

30 Jul 2012

publication

Apoptosis of mouse mast cells is reciprocally regulated by the IgG receptors FcγRIIB and FcγRIIIA

25 Apr 2012

publication

Properties of mouse and human IgG receptors and their contribution to disease models

02 Dec 2011

publication

Human FcγRIIA induces anaphylactic and allergic reactions

21 Oct 2011

publication

[An unexpected role for neutrophils in anaphylaxis]

01 Aug 2011

publication

A strain of Lactobacillus casei inhibits the effector phase of immune inflammation

23 Mar 2011

publication

Mouse and human neutrophils induce anaphylaxis

11 Feb 2011

publication

Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcγRIIIA-dependent mechanisms

19 Jan 2011

publication

Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis

20 Dec 2010

publication

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells

12 Feb 2010

publication

Differential recruitment of activating and inhibitory Fc gamma RII during phagocytosis

19 Oct 2009

publication

Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis

18 Nov 2008

publication

Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses

23 Oct 2008

publication

FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation

19 Dec 2005

publication

The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation

07 Oct 2005

publication

Regulation of allergy by Fc receptors

01 Jul 2005

publication

FcgammaRIV: a novel FcR with distinct IgG subclass specificity

21 Jan 2005

publication

Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia

28 Sep 2004

publication

Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap

20 Nov 2003

publication

Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes

01 Apr 2003

publication

A little guide for advanced search:

A monoclonal antibody collection for C.difficile typing ?

Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology.

4 X Quart d’heure Pasteur-médecine “CURARES en anesthésie – allergies et thérapies”

A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.

Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics.

Conditional neutrophil depletion challenges their contribution to mouse models of anaphylaxis.

New publication – A vaccine targeting human IL-4 and IL-13 protects against asthma in humanized mice

A vaccine targeting human IL-4 and IL-13 protects against asthma in humanized mice.

Isolation methods determine human neutrophil responses after stimulation.

High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura.

Specificity of mouse and human Fcgamma receptors and their polymorphic variants for IgG subclasses of different species.

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome

Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice.

Understanding protective humoral immunity in asymptomatic dengue-infected individuals

Antibodies as Drugs 2022 (Keystone Symposia)

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis

U1222 – Humoral Immunity

Antibodies and Complement conference 2023

High throughput selection of nanobodies by droplet based microfluidics (PTR nanofluidic)

Cellular stress and control of inflammation in autoimmune disease and cancer

Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.

Low end-tidal CO2 as a real-time severity marker of intra-anaesthetic acute hypersensitivity reactions.

Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring

Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide

In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.

Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice.

IgG subclasses determine pathways of anaphylaxis in mice

Microfluidics@Pasteur

Mouse and human FcR effector functions.

ERC-2013-CoG – 616050_MyeloSHOCK – Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples

DROPmAbs – Deep-mining of antibody repertoires using droplet-based microfluidics combined with barcoded deep sequencing for diagnostics and therapeutic antibody discovery

Role of platelets and their interactions in allergic diseases

Clinical and pathological consequences of human anti-drug antibodies (NASA study)

Developing novel models of disease and vaccination in Ab- and FcR-humanized mice

Antibody-based anti-tumor immunotherapy

METHODS FOR INHIBITING MAST CELL ACTIVATION AND TREATING MAST CELL-DEPENDENT INFLAMMATORY DISEASES AND DISORDERS USING LACTOBACILLUS

USE OF ANTl-FcyRI AND/OR ANTl-FcyRllA ANTIBODIES FOR TREATING ARTHRITIS, INFLAMMATION, THROMBOCYTOPENIA AND ALLERGIC SHOCK

Shaping mycolactone for therapeutic use against inflammatory disorders.

Antibodies in Therapy and Pathology

Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization

A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy

Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis

Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies

The function of Fcγ receptors in dendritic cells and macrophages

Neutrophils mediate antibody-induced antitumor effects in mice

Neutrophils in local and systemic antibody-dependent inflammatory and anaphylactic reactions

The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy

Quorum sensing contributes to activated IgM-secreting B cell homeostasis

Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma

A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia

Autonomous phagosomal degradation and antigen presentation in dendritic cells

Apoptosis of mouse mast cells is reciprocally regulated by the IgG receptors FcγRIIB and FcγRIIIA

Properties of mouse and human IgG receptors and their contribution to disease models

Human FcγRIIA induces anaphylactic and allergic reactions

[An unexpected role for neutrophils in anaphylaxis]

A strain of Lactobacillus casei inhibits the effector phase of immune inflammation

Mouse and human neutrophils induce anaphylaxis

Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcγRIIIA-dependent mechanisms

Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells

Differential recruitment of activating and inhibitory Fc gamma RII during phagocytosis

Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis

Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses

FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation

The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation

Regulation of allergy by Fc receptors

FcgammaRIV: a novel FcR with distinct IgG subclass specificity

Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia

Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap

Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes

Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease