Timeline

Pierre Bruhns
Head of Structure
10 Jul 2019
publication

An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis

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14 Feb 2019
team

Humorale Immunity

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14 Jan 2019
event

Antibodies and Complement conference

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07 Nov 2018
project

High throughput selection of nanobodies by droplet based microfluidics (PTR nanofluidic)

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04 Jun 2018
event

Cellular stress and control of inflammation in autoimmune disease and cancer

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13 Apr 2018
publication

Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.

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20 Oct 2017
publication

Low end-tidal CO2 as a real-time severity marker of intra-anaesthetic acute hypersensitivity reactions.

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11 Sep 2017
publication

Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring

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17 Feb 2017
publication

Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide

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10 Oct 2016
publication

In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.

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24 Aug 2016
publication

Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice.

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26 Apr 2016
publication

IgG subclasses determine pathways of anaphylaxis in mice.

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27 Oct 2015
project

Microfluidics@Pasteur

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26 Oct 2015
publication

Mouse and human FcR effector functions.

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22 Oct 2015
project

ERC-2013-CoG – 616050_MyeloSHOCK – Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples

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21 Oct 2015
project

DROPmAbs – Deep-mining of antibody repertoires using droplet-based microfluidics combined with barcoded deep sequencing for diagnostics and therapeutic antibody discovery

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20 Oct 2015
project

Role of platelets and their interactions in allergic diseases

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19 Oct 2015
project

Clinical and pathological consequences of human anti-drug antibodies (NASA study)

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18 Oct 2015
project

Developing novel models of disease and vaccination in Ab- and FcR-humanized mice

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17 Oct 2015
project

Antibody-based anti-tumor immunotherapy

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01 Sep 2015
patent

METHODS FOR INHIBITING MAST CELL ACTIVATION AND TREATING MAST CELL-DEPENDENT INFLAMMATORY DISEASES AND DISORDERS USING LACTOBACILLUS

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01 Sep 2015
patent

USE OF ANTl-FcyRI AND/OR ANTl-FcyRllA ANTIBODIES FOR TREATING ARTHRITIS, INFLAMMATION, THROMBOCYTOPENIA AND ALLERGIC SHOCK

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27 May 2015
publication

Shaping mycolactone for therapeutic use against inflammatory disorders

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11 May 2015
team

Antibodies in Therapy and Pathology

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17 Oct 2014
publication

Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization

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30 Jul 2014
publication

A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy

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25 Jul 2014
publication

Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis

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30 May 2014
publication

Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies

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21 Jan 2014
publication

The function of Fcγ receptors in dendritic cells and macrophages

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26 Aug 2013
publication

Neutrophils mediate antibody-induced antitumor effects in mice

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26 Mar 2013
publication

Neutrophils in local and systemic antibody-dependent inflammatory and anaphylactic reactions

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04 Jan 2013
publication

The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy

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03 Dec 2012
publication

Quorum sensing contributes to activated IgM-secreting B cell homeostasis

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12 Nov 2012
publication

Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma

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01 Sep 2012
publication

A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia

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20 Aug 2012
publication

Autonomous phagosomal degradation and antigen presentation in dendritic cells

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30 Jul 2012
publication

Apoptosis of mouse mast cells is reciprocally regulated by the IgG receptors FcγRIIB and FcγRIIIA

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25 Apr 2012
publication

Properties of mouse and human IgG receptors and their contribution to disease models

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02 Dec 2011
publication

Human FcγRIIA induces anaphylactic and allergic reactions

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21 Oct 2011
publication

[An unexpected role for neutrophils in anaphylaxis]

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01 Aug 2011
publication

A strain of Lactobacillus casei inhibits the effector phase of immune inflammation

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23 Mar 2011
publication

Mouse and human neutrophils induce anaphylaxis

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11 Feb 2011
publication

Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcγRIIIA-dependent mechanisms

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19 Jan 2011
publication

Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis

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20 Dec 2010
publication

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells

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12 Feb 2010
publication

Differential recruitment of activating and inhibitory Fc gamma RII during phagocytosis

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19 Oct 2009
publication

Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis

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18 Nov 2008
publication

Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses

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23 Oct 2008
publication

FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation

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19 Dec 2005
publication

The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation

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07 Oct 2005
publication

Regulation of allergy by Fc receptors

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01 Jul 2005
publication

FcgammaRIV: a novel FcR with distinct IgG subclass specificity

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21 Jan 2005
publication

Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia

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28 Sep 2004
publication

Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap

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20 Nov 2003
publication

Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes

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01 Apr 2003
publication

Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease

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