Ligne de temps
Pierre Bruhns
Responsable de Structure
11 sept. 2024
publication
Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models.
Lire plus19 janv. 2024
01 janv. 2024
publication
Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology.
Lire plus29 nov. 2023
25 août 2023
publication
A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.
Lire plus10 juil. 2023
publication
Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics.
Lire plus06 avr. 2023
publication
Conditional neutrophil depletion challenges their contribution to mouse models of anaphylaxis.
Lire plus13 mars 2023
news
New publication – A vaccine targeting human IL-4 and IL-13 protects against asthma in humanized mice
Lire plus17 févr. 2023
publication
A vaccine targeting human IL-4 and IL-13 protects against asthma in humanized mice.
Lire plus01 janv. 2023
03 mai 2022
publication
High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura.
Lire plus08 févr. 2022
publication
Specificity of mouse and human Fcgamma receptors and their polymorphic variants for IgG subclasses of different species.
Lire plus03 sept. 2021
publication
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome
Lire plus11 mai 2021
publication
Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice.
Lire plus01 sept. 2020
project
Understanding protective humoral immunity in asymptomatic dengue-infected individuals
Lire plus17 déc. 2019
06 nov. 2019
publication
An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
Lire plus10 juil. 2019
publication
An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis
Lire plus14 févr. 2019
14 janv. 2019
07 nov. 2018
project
High throughput selection of nanobodies by droplet based microfluidics (PTR nanofluidic)
Lire plus04 juin 2018
13 avr. 2018
publication
Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.
Lire plus20 oct. 2017
publication
Low end-tidal CO2 as a real-time severity marker of intra-anaesthetic acute hypersensitivity reactions.
Lire plus11 sept. 2017
publication
Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring
Lire plus17 févr. 2017
publication
Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide
Lire plus10 oct. 2016
publication
In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.
Lire plus24 août 2016
publication
Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice.
Lire plus26 avr. 2016
27 oct. 2015
26 oct. 2015
01 sept. 2015
patent
METHODS FOR INHIBITING MAST CELL ACTIVATION AND TREATING MAST CELL-DEPENDENT INFLAMMATORY DISEASES AND DISORDERS USING LACTOBACILLUS
Lire plus01 sept. 2015
patent
USE OF ANTl-FcyRI AND/OR ANTl-FcyRllA ANTIBODIES FOR TREATING ARTHRITIS, INFLAMMATION, THROMBOCYTOPENIA AND ALLERGIC SHOCK
Lire plus27 mai 2015
11 mai 2015
17 oct. 2014
publication
Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization
Lire plus30 juil. 2014
publication
A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy
Lire plus25 juil. 2014
publication
Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis
Lire plus30 mai 2014
publication
Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies
Lire plus21 janv. 2014
26 août 2013
26 mars 2013
publication
Neutrophils in local and systemic antibody-dependent inflammatory and anaphylactic reactions
Lire plus04 janv. 2013
publication
The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy
Lire plus03 déc. 2012
12 nov. 2012
publication
Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma
Lire plus01 sept. 2012
publication
A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia
Lire plus20 août 2012
30 juil. 2012
publication
Apoptosis of mouse mast cells is reciprocally regulated by the IgG receptors FcγRIIB and FcγRIIIA
Lire plus25 avr. 2012
publication
Properties of mouse and human IgG receptors and their contribution to disease models
Lire plus02 déc. 2011
21 oct. 2011
01 août 2011
publication
A strain of Lactobacillus casei inhibits the effector phase of immune inflammation
Lire plus23 mars 2011
11 févr. 2011
publication
Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcγRIIIA-dependent mechanisms
Lire plus19 janv. 2011
publication
Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis
Lire plus20 déc. 2010
publication
Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells
Lire plus12 févr. 2010
publication
Differential recruitment of activating and inhibitory Fc gamma RII during phagocytosis
Lire plus19 oct. 2009
publication
Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis
Lire plus18 nov. 2008
publication
Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
Lire plus23 oct. 2008
publication
FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation
Lire plus19 déc. 2005
publication
The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation
Lire plus07 oct. 2005
01 juil. 2005
21 janv. 2005
publication
Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia
Lire plus28 sept. 2004
publication
Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap
Lire plus20 nov. 2003
publication
Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes
Lire plus01 avr. 2003
publication