Timeline

Patrick England
Head of Facility
04 Jun 2021
publication

SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system.

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01 Jun 2020
publication

High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

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27 Mar 2020
publication

Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.

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30 Jan 2020
publication

Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein.

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06 Dec 2019
publication

X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications.

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26 Sep 2018
publication

An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins

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01 Sep 2018
publication

An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins

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29 Mar 2018
event

Multimodal Light and Electron Microscopy in an advanced Core Facility

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01 Mar 2018
publication

Biophysical Approaches to Protein Folding and Disease, a satellite meeting to the IUPAB-EBSA congress

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15 Jan 2018
publication

The stress sigma factor of RNA polymerase RpoS/σ is a solvent-exposed open molecule in solution

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12 Jan 2018
publication

Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough

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13 Dec 2017
event

Prof. BÜLL Alexander “Insights into the mechanism of amyloid fibril formation by alpha-synuclein”

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05 Dec 2017
publication

Facile immobilization of DNA using an enzymatic his-tag mimic

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14 Nov 2017
publication

Facile immobilization of DNA using an enzymatic his-tag mimic

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03 Nov 2017
publication

A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion

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11 Sep 2017
publication

Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring

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10 Jul 2017
publication

Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery

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13 Jun 2017
publication

Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening

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16 May 2017
publication

Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2

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05 May 2017
event

2nd QBio symposium : mechanical forces in biology

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28 Apr 2017
publication

Erratum: High affinity anchoring of the decoration protein pb10 onto the bacteriophage T5 capsid

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06 Feb 2017
publication

High affinity anchoring of the decoration protein pb10 onto the bacteriophage T5 capsid

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27 Jan 2017
event

HDX-MS/NMR DAY

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10 Nov 2016
publication

Erratum: Structural basis of potent Zika-dengue virus antibody cross-neutralization.

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26 Oct 2016
publication

Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc

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13 Sep 2016
publication

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes

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18 Aug 2016
publication

Correction: The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH

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30 Jul 2016
publication

Efficient monitoring of protein ubiquitylation levels using TUBEs-based microarrays

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23 Jun 2016
publication

Structural basis of potent Zika-dengue virus antibody cross-neutralization

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26 Apr 2016
publication

IgG subclasses determine pathways of anaphylaxis in mice

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20 Apr 2016
event

Do not forget the next Citech seminar with Dr Ulf Landegren !

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12 Apr 2016
publication

The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH

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27 Mar 2016
project

FlexBiVac

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25 Mar 2016
publication

The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation

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01 Jan 2016
publication

Real-Time Surface Plasmon Resonance (SPR) for the Analysis of Interactions Between SUMO Traps and Mono- or PolySUMO Moieties

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20 Nov 2015
project

Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA

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23 Oct 2015
publication

The Stable Interaction Between Signal Peptidase LepB of Escherichia coli and Nuclease Bacteriocins Promotes Toxin Entry into the Cytoplasm

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23 Oct 2015
publication

The Stable Interaction Between Signal Peptidase LepB of Escherichia coli and Nuclease Bacteriocins Promotes Toxin Entry into the Cytoplasm

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12 Sep 2015
project

CarbUniVax

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17 Aug 2015
project

CyaA secretion, folding and translocation across membrane

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05 Aug 2015
publication

A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus

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21 May 2015
publication

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

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13 May 2015
publication

The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid

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17 Mar 2015
publication

A Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase Signaling

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17 Feb 2015
team

Molecular Biophysics

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07 Jan 2015
publication

Identification and characterization of the binding site of the respiratory syncytial virus phosphoprotein to RNA-free nucleoprotein

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30 Dec 2014
publication

Quality assessment and optimization of purified protein samples: why and how?

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15 Dec 2014
publication

Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: potential implications in breast tumorigenesis

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03 Dec 2014
publication

Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies

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15 Oct 2014
publication

Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase

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11 Apr 2014
publication

Interaction of a partially disordered antisigma factor with its partner, the signaling domain of the TonB-dependent transporter HasR

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18 Nov 2013
publication

Structural basis of myosin V Rab GTPase-dependent cargo recognition

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30 Apr 2013
publication

Hydrodynamic characterization of recombinant human fibrinogen species

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18 Mar 2013
publication

SUN proteins belong to a novel family of β-(1,3)-glucan-modifying enzymes involved in fungal morphogenesis

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30 Jan 2013
publication

The α-helical regions of KERP1 are important in Entamoeba histolytica adherence to human cells

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04 Jan 2013
publication

The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy

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01 Jan 2013
publication

Analysis of SUMOylated proteins using SUMO-traps

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13 Sep 2012
publication

Citrullination of histone H3 interferes with HP1-mediated transcriptional repression

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26 Mar 2012
publication

Transglutaminase is essential for IgA nephropathy development acting through IgA receptors

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09 Dec 2011
publication

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

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21 Nov 2011
publication

Pilotin-secretin recognition in the type II secretion system of Klebsiella oxytoca

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15 Sep 2011
publication

Characterization of the elongasome core PBP2 : MreC complex of Helicobacter pylori

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01 Jul 2011
publication

Insights into the Rrf2 repressor family–the structure of CymR, the global cysteine regulator of Bacillus subtilis

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14 Mar 2011
publication

Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition

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01 Dec 2010
publication

Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin

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08 Oct 2010
publication

Crl binds to domain 2 of σ(S) and confers a competitive advantage on a natural rpoS mutant of Salmonella enterica serovar Typhi

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16 Jul 2010
publication

Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

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01 Apr 2010
publication

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

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19 Feb 2010
publication

The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule

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02 Oct 2009
publication

Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities

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18 Aug 2009
publication

Novel svVEGF isoforms from Macrovipera lebetina venom interact with neuropilins

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27 Nov 2008
publication

A global benchmark study using affinity-based biosensors

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18 Nov 2008
publication

Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses

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23 Oct 2008
publication

FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation

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18 Oct 2008
publication

Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation

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25 Sep 2008
publication

Binding of the unorthodox transcription activator, Crl, to the components of the transcription machinery

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04 Sep 2007
publication

Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL

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14 Aug 2007
publication

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential

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08 Jun 2007
publication

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity

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01 Jun 2007
publication

Clostridium difficile toxin expression is inhibited by the novel regulator TcdC

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07 Feb 2007
publication

Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis

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15 Aug 2006
publication

Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons

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25 Apr 2006
publication

Characterization of the non-native trifluoroethanol-induced intermediate conformational state of the Shiga toxin B-subunit

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01 Jan 2006
publication

The scc spirochetal coiled-coil protein forms helix-like filaments and binds to nucleic acids generating nucleoprotein structures

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01 Jan 2006
publication

Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus

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01 Sep 2005
publication

Stable trimerization of recombinant rabies virus glycoprotein ectodomain is required for interaction with the p75NTR receptor

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24 Feb 2005
publication

Energetics of 5-bromo-4-chloro-3-indolyl-alpha-D-mannose binding to the Parkia platycephala seed lectin and its use for MAD phasing

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29 Jul 2004
publication

Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.

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23 Apr 2004
publication

Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3

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20 Feb 2004
publication

A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor

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30 Oct 2003
publication

A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients

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07 Jul 2003
publication

The N-terminal domain of hepatocyte growth factor inhibits the angiogenic behavior of endothelial cells independently from binding to the c-met receptor

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01 Sep 2002
publication

Harnessing malE for the study of antigen/antibody recognitions

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01 Aug 2002
publication

Several regions of the repeat domain of the Staphylococcus caprae autolysin, AtlC, are involved in fibronectin binding

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26 Apr 2002
publication

Knowledge-based design of reagentless fluorescent biosensors from recombinant antibodies

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