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© Sandrine Etienne-Manneville
Photo prise à l'avant (dans la protrusion) d'astrocytes primaires de rat en migration. Marquage par immunofluorescence montrant en rouge, p150 Glued, une protéine associée aux extrémités 'plus' des microtubules et en vert la tubuline des microtubules. La photographie montre l'accumulation de p150 Glued à l'avant des cellules en migration, où la protéine pourrait participer à l'ancrage des microtubules à la membrane plasmique. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaires.
Publication : PloS one

Correction: The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH

Team: BiophysiCyaA
Team: Biochemistry of Macromolecular Interactions
Team: Molecular Biophysics
Member: Patrick England
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 18 Aug 2016

Araye A, Goudet A, Barbier J, Pichard S, Baron B, England P, Pérez J, Zinn-Justin S, Chenal A, Gillet D