Inserm Unit 1223 (Pathophysiology of the Immune System) comprises four laboratories within the Immunology Department of the Institut Pasteur: Innate Immunity Unit (James Di Santo), Lymphocytes and Immunity Unit (Ana Cumano), Dynamics of Immune Response Unit (Philippe Bousso) and Genome Integrity Immunity and Cancer Unit (Ludovic Deriano). Together, we pursue collaborative projects aiming to better understand lymphocyte development, differentiation and functional dynamics under normal steady-state conditions and during inflammation or infection in mouse and man.
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About
Members
Groups
Laboratory
Dynamics of Immune Responses
Philippe Bousso
Laboratory
Innate Immunity
James Di Santo
Laboratory
Genome integrity, Immunity and Cancer
Ludovic Deriano
Fundings
Publications
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2024A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model., J Virol 2024 Apr; (): e0169323.
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2024Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes., J Exp Med 2024 Apr; 221(4): .
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2024Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis, Cell Reports, 2024, 43 (1), pp.113676. ⟨10.1016/j.celrep.2024.113676⟩.
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2023A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses., Eur J Immunol 2023 Aug; (): e2350454.
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2023A major role for CD4+ T cells in driving cytokine release syndrome during CAR T cell therapy., Cell Rep Med 2023 Aug; (): 101161.
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2023Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity., Nat Cancer 2023 May; (): .
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2023Tissue-resident memory T cells mediate mucosal immunity to recurrent urinary tract infection., Sci Immunol 2023 May; 8(83): eabn4332.
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2023Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics., iScience 2023 Feb; 26(2): 106068.
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2023Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria., Cell 2023 Feb; 186(3): 621-645.e33.
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2022The immune factors driving DNA methylation variation in human blood., Nat Commun 2022 Oct; 13(1): 5895.
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