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  • Physician
  • Post-doc
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  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
02
Sep 2013
Status
Ongoing
Members
9
Structures
4

About

The behaviour of muscle stem cells during sepsis

Sepsis is an uncontrolled immune reaction that occurs in approximately 2% of all hospitalizations in developed countries. Patients die in 30% of the cases (up to 50% in case of severe septis). Among survivors, half of them will develop acquired neuromyopathy (a loss of muscle mass and strength) that can last up to 5 years.

It is known that this loss of muscle mass is due to an over destruction of proteins. However, muscle is a tissue that has incredible capacity to regenerate when injured thanks to its stem cells called the satellite cells.

Our project is to study the behaviour of muscle stem cells that we have shown to be impaired during and after a sepsis and find a way to make them functional again in order for them to insure normal muscle homeostasis.

Fundings