The behaviour of muscle stem cells during sepsis
Sepsis is an uncontrolled immune reaction that occurs in approximately 2% of all hospitalizations in developed countries. Patients die in 30% of the cases (up to 50% in case of severe septis). Among survivors, half of them will develop acquired neuromyopathy (a loss of muscle mass and strength) that can last up to 5 years.
It is known that this loss of muscle mass is due to an over destruction of proteins. However, muscle is a tissue that has incredible capacity to regenerate when injured thanks to its stem cells called the satellite cells.
Our project is to study the behaviour of muscle stem cells that we have shown to be impaired during and after a sepsis and find a way to make them functional again in order for them to insure normal muscle homeostasis.