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  • Undergraduate Student
  • Veterinary
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  • Director of Center
  • Director of Department
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© Research
Publication : Frontiers in physiology

Danger signals in traumatic hemorrhagic shock and new lines for clinical applications.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Frontiers in physiology - 01 Jan 2022

Dufour-Gaume F, Frescaline N, Cardona V, Prat NJ,

Link to Pubmed [PMID] – 36726379

Link to DOI – 99901110.3389/fphys.2022.999011

Front Physiol 2022 ; 13(): 999011

Hemorrhage is the leading cause of death in severe trauma injuries. When organs or tissues are subjected to prolonged hypoxia, danger signals-known as damage-associated molecular patterns (DAMPs)-are released into the intercellular environment. The endothelium is both the target and a major provider of damage-associated molecular patterns, which are directly involved in immuno-inflammatory dysregulation and the associated tissue suffering. Although damage-associated molecular patterns release begins very early after trauma, this release and its consequences continue beyond the initial treatment. Here we review a few examples of damage-associated molecular patterns to illustrate their pathophysiological roles, with emphasis on emerging therapeutic interventions in the context of severe trauma. Therapeutic intervention administered at precise points during damage-associated molecular patterns release may have beneficial effects by calming the inflammatory storm triggered by traumatic hemorrhagic shock.